CTLA4 +49AG (rs231775) and CT60 (rs3087243) gene variants are not associated with alopecia areata in a Mexican population from Monterrey Mexico
An. bras. dermatol
;
95(3): 283-288, May-June 2020. tab
Article
Dans Anglais
| LILACS, ColecionaSUS
| ID: biblio-1130886
ABSTRACT
Abstract Background:
Alopecia areata is an autoimmune disease that produces non-scarring hair loss around the body. Gene variants of the cytotoxic T-lymphocyte antigen 4 (CTLA4) gene, a negative regulator of T-cell response, have been associated with a predisposition to autoimmune diseases in different populations; however, the involvement of these genetic variants in the development of AA is controversial.Objective:
The present study evaluated the potential association of two CTLA4 gene variants with alopecia areata in a Mexican population.Methods:
We genotyped +49AG (rs231775) and CT60 (rs3087243) variants in 50 AA patients and 100 healthy control participants through PCR-RFLP.Results:
No statistical difference was observed for either of the gene variants regarding allele or genotype frequencies between AA patients and the controls when the parameters of family/personal history of autoimmune diseases or gender were considered (p > 0.05). Studylimitations:
Small sample size of patients and the data were obtained from Northeast Mexico population.Conclusion:
The genetic variants rs231775 and rs3087243 of the CTLA4 gene are not a risk factor for the development of alopecia areata in the analyzed Mexican population.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Variation génétique
/
Pelade
/
Antigène CTLA-4
Type d'étude:
Etude d'étiologie
/
Étude observationnelle
/
Étude pronostique
/
Facteurs de risque
Limites du sujet:
Adolescent
/
Adulte
/
Femelle
/
Humains
/
Mâle
Pays comme sujet:
Mexico
langue:
Anglais
Texte intégral:
An. bras. dermatol
Année:
2020
Type:
Article
Institution/Pays d'affiliation:
Universidad Autónoma de Coahuila/MX
/
Universidad Autónoma de Nuevo León/MX
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