Spitz nevus and infliximab: association or coincidence?
An. bras. dermatol
;
95(5): 615-618, Sept.-Oct. 2020. graf
Article
Dans Anglais
| LILACS, ColecionaSUS
| ID: biblio-1130930
ABSTRACT
Abstract Biological therapies, including anti-TNF agents, are important in the treatment of various chronic inflammatory diseases, including psoriasis, rheumatoid arthritis or inflammatory bowel disease. The increased use of these drugs translates into an increasing awareness of its adverse effects, which include malignancy. In this paper, we describe the case of a 28-year-old woman who developed a spitzoid melanocytic tumor after starting infliximab therapy for ulcerative colitis. The evidence for causality between anti-TNF and melanocytic proliferations is still sparse; nonetheless, treatment-associated immunosuppression seems to play a key role in this phenomenon. Therefore, a regular follow-up with a rigorous skin examination is essential in these patients. Noninvasive techniques such as dermoscopy or reflectance confocal microscopy are particularly useful diagnostic tools in these circumstances.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Tumeurs cutanées
/
Naevus à cellules épithelioïdes et fusiformes
Type d'étude:
Etude diagnostique
/
Facteurs de risque
Limites du sujet:
Adulte
/
Femelle
/
Humains
langue:
Anglais
Texte intégral:
An. bras. dermatol
Année:
2020
Type:
Article
Institution/Pays d'affiliation:
Centro Hospitalar e Universitário de Lisboa Norte/PT
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