Metanephric Adenoma with cystic changes- An uncommon presentation of a rare tumor in a young adult
Autops. Case Rep
;
10(3): e2020148, 2020. graf
Article
Dans Anglais
| LILACS
| ID: biblio-1131827
ABSTRACT
Metanephric adenoma (MA) is a rare benign neoplasm of the kidney that is usually asymptomatic and incidentally diagnosed. MA usually present as a solid mass; however, a cystic presentation has been reported. The main differential diagnosis of MA is the epithelial predominant Wilms tumor (e-WT) and the solid variant of papillary renal cell carcinoma (pRCC). The presence of the BRAF gene mutation has recently been reported in 85% of MA, and less than 10% of cases of MA do not express this specific gene mutation. Herein we report a 22-year-old man who presented with back pain and abdominal discomfort with a renal mass on the computed tomographic scan. The diagnosis of metanephric adenoma was confirmed histopathologically. In our case, the tumor presented as a solid and cystic mass hence mimicking a papillary renal cell carcinoma. The VE1 protein, which correlates with BRAF gene mutation, did not show any significant expression. We want to highlight that MA can present as a cystic lesion that should be taken into account to avoid unnecessary radical nephrectomy. Also, we demonstrated that a subset of MA might not harbor the BRAF gene and, they are classified as the BRAF wild type MA.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Adénomes
/
Protéines proto-oncogènes B-raf
/
Tumeurs du rein
Type d'étude:
Etude diagnostique
Limites du sujet:
Adulte
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Autops. Case Rep
Thème du journal:
Anatomia
/
Patologia Cl¡nica
/
Patologia Legal
Année:
2020
Type:
Article
Pays d'affiliation:
Inde
Institution/Pays d'affiliation:
North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences/IN
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS