Disseminated cryptococcosis and hemochromatosis: clues to diagnosis
Autops. Case Rep
;
10(3): e2020180, 2020. graf
Article
Dans Anglais
| LILACS
| ID: biblio-1131840
ABSTRACT
Hepatic cirrhosis, diabetes mellitus and iron overload can each independently predispose to cryptococcosis. Hereditary hemochromatosis leads to all three of these predispositions. This report is the case of a patient with chronic hepatitis B virus infection and cirrhosis, who had markedly elevated serum ferritin and 99% transferrin saturation, and developed a leukemoid reaction. Autopsy revealed disseminated cryptococcosis for which the leukemoid reaction was a clue and possible hereditary hemochromatosis of which elevated ferritin and transferrin saturation can be clues. Hereditary hemochromatosis is an important diagnosis clinicians should never miss because early treatment with phlebotomy can be life-saving. Disseminated cryptococcosis can be rapidly diagnosed with serum cryptococcal antigen test and is treatable.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Cryptococcose
/
Hémochromatose
Type d'étude:
Etude diagnostique
Limites du sujet:
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Autops. Case Rep
Thème du journal:
Anatomia
/
Patologia Cl¡nica
/
Patologia Legal
Année:
2020
Type:
Article
Pays d'affiliation:
États-Unis d'Amérique
Institution/Pays d'affiliation:
Mercer University School of Medicine/US
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