Treatment Eligibility and Therapeutic Responses of an Ecuadorian Population at High Cardiovascular Risk Based on the ATP III Guidelines
Int. j. cardiovasc. sci. (Impr.)
;
33(4): 371-376, July-Aug. 2020. tab, graf
Article
Dans Anglais
| LILACS
| ID: biblio-1134382
ABSTRACT
Abstract Background The Adult Treatment Panel III (ATPIII) guidelines aim to reduce cardiovascular morbidity and mortality. In Ecuador, 20% of people have high LDL cholesterol levels, and 39% have high triglyceride levels. Objective To analyze lipid-lowering regimens in Ecuadorian patients and determine the achievement rate of the ATPIII goals for lipid profile. Methods Using a retrospective analysis, 385 subjects older than 30 years, who received pharmacological treatment for dyslipidemia for at least three months was randomly selected from institutions at two large cities in Ecuador. Data were collected from patients' medical records and analyzed by chi-square test or paired t-test; p-values less than 0.05 were considered significant. Results Baseline total cholesterol values were above 200 mg/dL in 75% of subjects, LDL-c values above 129 mg/dL in 83% of subjects and triglycerides values above 150 mg/dL in 79% of subjects. Most (n = 253, 95.8%) patients at very high cardiovascular risk were taking statins, 50% of them atorvastatin. Considering the ATPIII guidelines' goals, only 24 subjects (19%) at high CV risk achieved an LDL-c < 100 mg/dl, while a significantly lower percentage (p = 0.04) of patients at very high risk reached an LDL-c < 70mg/dl (11%; n = 30). Conclusion These data indicate a low rate of compliance with the ATPIII guidelines, independent of the medication used or duration of the treatment. This may be attributed to the prescription of low doses of medication and a therapy targeting isolated lipid fractions rather than a complete lipid profile. (Int J Cardiovasc Sci. 2020; 33(4)371-376)
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Maladies cardiovasculaires
/
Hypolipémiants
Type d'étude:
Etude d'étiologie
/
Guide de pratique
/
Étude observationnelle
/
Facteurs de risque
Limites du sujet:
Adulte très âgé
/
Femelle
/
Humains
/
Mâle
Pays comme sujet:
Amérique du Sud
/
Equateur
langue:
Anglais
Texte intégral:
Int. j. cardiovasc. sci. (Impr.)
Thème du journal:
Cardiologie
Année:
2020
Type:
Article
Pays d'affiliation:
Équateur
Institution/Pays d'affiliation:
Hospital Carlos Andrade Marín/EC
/
Hospital Luis Vernaza/EC
/
Hospital Teodoro Maldonado Carbo/EC
/
Hospital de Especialidades Eugenio Espejo/EC
/
Pontificia Universidad Católica del Ecuador/EC
/
Universidad San Francisco de Quito/EC
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