Increased levels of reactive oxygen species in platelets and platelet-derived microparticles and the risk of respiratory failure in HIV/AIDS patients
Mem. Inst. Oswaldo Cruz
;
115: e200082, 2020. tab, graf
Article
Dans Anglais
| LILACS, SES-SP
| ID: biblio-1135226
ABSTRACT
Respiratory failure (RF) is the main cause of hospital admission in HIV/AIDS patients. This study assessed comorbidities and laboratory parameters in HIV/AIDS inpatients with RF (N = 58) in relation to those without RF (N = 36). Tuberculosis showed a huge relative risk and platelet counts were slightly higher in HIV/AIDS inpatients with RF. A flow cytometry assay for reactive oxygen species (ROS) showed lower levels in platelets of these patients in relation to the healthy subjects. However, when stimulated with adrenaline, ROS levels increased in platelets and platelet-derived microparticles of HIV/AIDS inpatients, which may increase the risk of RF during HIV and tuberculosis (HIV-TB) coinfection.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Insuffisance respiratoire
/
Infections à VIH
/
VIH (Virus de l'Immunodéficience Humaine)
/
Espèces réactives de l'oxygène
/
Microparticules membranaires
Type d'étude:
Etude d'étiologie
/
Facteurs de risque
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Mem. Inst. Oswaldo Cruz
Année:
2020
Type:
Article
Institution/Pays d'affiliation:
Fundação Oswaldo Cruz-Fiocruz/BR
/
Fundação de Medicina Tropical Heitor Vieira Dourado/BR
/
Universidade Federal do Amazonas/BR
/
Universidade do Estado do Amazonas/BR
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