COVID-19: molecular targets, drug repurposing and new avenues for drug discovery
Mem. Inst. Oswaldo Cruz
;
115: e200254, 2020. tab, graf
Article
Dans Anglais
| LILACS, SES-SP
| ID: biblio-1135246
ABSTRACT
Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly contagious infection that may break the healthcare system of several countries. Here, we aimed at presenting a critical view of ongoing drug repurposing efforts for COVID-19 as well as discussing opportunities for development of new treatments based on current knowledge of the mechanism of infection and potential targets within. Finally, we also discuss patent protection issues, cost effectiveness and scalability of synthetic routes for some of the most studied repurposing candidates since these are key aspects to meet global demand for COVID-19 treatment.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Pneumopathie virale
/
Infections à coronavirus
/
Découverte de médicament
/
Repositionnement des médicaments
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Mem. Inst. Oswaldo Cruz
Année:
2020
Type:
Article
Institution/Pays d'affiliation:
Fundação Oswaldo Cruz-Fiocruz/BR
/
Universidade Federal do Rio de Janeiro/BR
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