Covid-19 - endothelial axis and coronary artery bypass graft patency: a target for therapeutic intervention?
Rev. bras. cir. cardiovasc
;
35(5): 757-763, Sept.-Oct. 2020. tab, graf
Article
Dans Anglais
| LILACS, SES-SP
| ID: biblio-1137320
ABSTRACT
Abstract It has been reported that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection induces endothelial inflammation, therefore facilitating the progression of endothelial and vascular dysfunction in coronavirus disease 2019 (COVID-19) patients. Coronary artery bypass grafting (CABG) involves mainly the use of the saphenous vein (SV) and internal mammary artery as graft material in the stenosed coronary arteries. Unfortunately, graft patency of the SV is low due to endothelial dysfunction and inflammation. We propose that SARS-CoV-2 might cause vascular inflammation, endothelial dysfunction, and thrombosis in coronary artery bypass graft vessels by binding angiotensin-converting enzyme 2 receptor. Therefore, in this Special Article, we consider the potential influence of COVID-19 on the patency rates of coronary artery bypass graft vessels, mainly with reference to the SV. Moreover, we discuss the technique of SV graft harvesting and the therapeutic potential of focusing on endothelial dysfunction, vascular inflammation, and thrombosis for protecting coronary artery bypass grafts in COVID-19 infected CABG patients.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Degré de perméabilité vasculaire
/
Pontage aortocoronarien
/
Infections à coronavirus
/
Occlusion du greffon vasculaire
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Rev. bras. cir. cardiovasc
Année:
2020
Type:
Article
Institution/Pays d'affiliation:
Istanbul University/TR
/
University College Medical School/GB
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