Association of the polymorphism Exon 1 (A/O) region of the mannose-binding lectin gene and periportal fibrosis regression in schistosomiasis after specific treatment
Rev. Soc. Bras. Med. Trop
;
54: e01452020, 2021. tab, graf
Article
Dans Anglais
| SES-SP, ColecionaSUS, LILACS
| ID: biblio-1143891
ABSTRACT
Abstract INTRODUCTION:
We evaluated the association between genetic polymorphisms in exon 1 (A/O alleles) and promoter regions at positions -550 (H/L variant, rs11003125) and -221 (X/Y variant, rs7096206) MBL2 and periportal fibrosis regression.METHODS:
This was a retrospective cohort study involving 114 Brazilians infected with Schistosoma mansoni, who were subjected to follow-up for three years after specific treatment for schistosomiasis to estimate the probability of periportal fibrosis regression.RESULTS:
A risk association was observed between polymorphism at the exon 1 MBL2 and periportal fibrosis regression.CONCLUSIONS:
This study suggests that the polymorphism of exon 1 MBL2 may potentially be used to predict periportal fibrosis regression in this population.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Schistosomiase
/
Lectine liant le mannose
Type d'étude:
Étude observationnelle
/
Étude pronostique
/
Facteurs de risque
Limites du sujet:
Animaux
/
Humains
Pays comme sujet:
Amérique du Sud
/
Brésil
langue:
Anglais
Texte intégral:
Rev. Soc. Bras. Med. Trop
Année:
2021
Type:
Article
Institution/Pays d'affiliation:
Universidade Federal de Pernambuco/BR
/
Universidade de Pernambuco/BR
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