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Associations between serum calcium, 25(OH)D level and bone mineral density in adolescents
Pan, Kaiyu; Tu, Rongliang; Yao, Xiaocong; Zhu, Zhongxin.
  • Pan, Kaiyu; Xiaoshan Affiliated Hospital of Wenzhou Medical University. Department of Paediatrics. Hangzhou. CN
  • Tu, Rongliang; Zhejiang Xiaoshan Hospital. Department of Paediatrics. Hangzhou. CN
  • Yao, Xiaocong; Xiaoshan Affiliated Hospital of Wenzhou Medical University. Department of Osteoporosis Care and Control. Hangzhou. CN
  • Zhu, Zhongxin; Xiaoshan Affiliated Hospital of Wenzhou Medical University. Department of Osteoporosis Care and Control. Hangzhou. CN
Adv Rheumatol ; 61: 16, 2021. tab, graf
Article Dans Anglais | LILACS | ID: biblio-1152746
ABSTRACT
Abstract Backgrounds It is important to improve our understanding of the roles of calcium and vitamin D in bone health for preventing osteoporosis. We aimed at exploring the associations between serum calcium, vitamin D level, and bone mineral density (BMD) in adolescents included in the National Health and Nutrition Examination Survey (NHANES) 2001 - 2006.

Methods:

Weighted multivariate linear regression models were used to estimate the associations of serum calcium, 25(OH)D level with total BMD. Smooth curve fitting was used to explore the potential non-linear relationship.

Results:

A total of 5990 individuals aged between 12 and 19 years were included in this study. The fully-adjusted model showed serum calcium positively correlated with total BMD. However, an inverted U-shaped relationship was found when we performed the smooth curve fitting method, and the inflection point was calculated at 9.6 mg/dL using the two-piecewise linear regression model. In contrast, there was a positive correlation between serum 25(OH)D and total BMD after adjusting for potential confounders.

Conclusions:

The present study revealed a positive correlation between serum 25(OH)D level and total BMD, and an inverted U-shaped relationship between serum calcium and total BMD.(AU)
Sujets)


Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Vitamine D / Densité osseuse / Calcium Type d'étude: Étude pronostique / Facteurs de risque Limites du sujet: Adolescent / Humains langue: Anglais Texte intégral: Adv Rheumatol Thème du journal: Artrite / Reumatologia Année: 2021 Type: Article Pays d'affiliation: Chine Institution/Pays d'affiliation: Xiaoshan Affiliated Hospital of Wenzhou Medical University/CN / Zhejiang Xiaoshan Hospital/CN

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Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Vitamine D / Densité osseuse / Calcium Type d'étude: Étude pronostique / Facteurs de risque Limites du sujet: Adolescent / Humains langue: Anglais Texte intégral: Adv Rheumatol Thème du journal: Artrite / Reumatologia Année: 2021 Type: Article Pays d'affiliation: Chine Institution/Pays d'affiliation: Xiaoshan Affiliated Hospital of Wenzhou Medical University/CN / Zhejiang Xiaoshan Hospital/CN