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Invasive pneumococcal disease in children with cancer: Incidence density, risk factors and isolated serotypes
Lages, Pedro Mendes; Carlesse, Fabianne; Boettger, Bruno Cruz; Pignatari, Antônio Carlos Campos; Petrilli, Antônio Sérgio; Moraes-Pinto, Maria Isabel de.
  • Lages, Pedro Mendes; Universidade Federal de São Paulo. Departamento de Pediatria. São Paulo. BR
  • Carlesse, Fabianne; Universidade Federal de São Paulo. Departamento de Pediatria. São Paulo. BR
  • Boettger, Bruno Cruz; Universidade Federal de São Paulo. Departamento de MedicinaDivisão de Doenças Infecciosas. São Paulo. BR
  • Pignatari, Antônio Carlos Campos; Universidade Federal de São Paulo. Departamento de MedicinaDivisão de Doenças Infecciosas. São Paulo. BR
  • Petrilli, Antônio Sérgio; Universidade Federal de São Paulo. Departamento de Pediatria. São Paulo. BR
  • Moraes-Pinto, Maria Isabel de; Universidade Federal de São Paulo. Departamento de Pediatria. São Paulo. BR
Braz. j. infect. dis ; 24(6): 489-496, Nov.-Dec. 2020. tab, graf
Article Dans Anglais | LILACS | ID: biblio-1153497
ABSTRACT
ABSTRACT

Background:

Pediatric oncology patients (POP) have a high risk of infections due to impaired immunity. Invasive pneumococcal disease (IPD) is an important cause of severe infection in these patients and it is associated with high mortality. This study aimed to evaluate the incidence and risk factors associated with IPD at a Pediatric Oncology Center in Brazil.

Methods:

This was a retrospective case-control study. All IPD cases in children with cancer from 2005 through 2016 were reviewed. Each case of IPD was matched with two controls from a cohort of patients matched for year of IPD, age and disease in order to assess risk factors. The incidence density was calculated as the number of IPD per 100,000 patients-year.

Results:

A total of 51 episodes of IPD in 49 patients was identified. All pneumococci were isolated from blood cultures. The median age was five years and 67% were male; mortality rate was 7.8%. The IPD incidence density rate in POP was 311.21 per 100,000 patients-year, significantly higher than the rate in the general pediatric population. Severe neutropenia was the only risk factor associated with IPD, after multivariate conditional logistic regression analysis.

Conclusion:

Although pneumococcal disease decreased after the introduction of 10-valent pneumococcal vaccine in the Brazilian national immunization schedule in 2010, there was no decrease in the IPD incidence rate in our cohort. A higher coverage rate of pneumococcal vaccination in children in the general population might be necessary to reduce the incidence rate in this high-risk population.
Sujets)


Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Infections à pneumocoques / Tumeurs Type d'étude: Etude d'étiologie / Etude d'incidence / Étude observationnelle / Étude pronostique / Facteurs de risque Limites du sujet: Enfant / Enfant d'âge préscolaire / Femelle / Humains / Bébé / Mâle Pays comme sujet: Amérique du Sud / Brésil langue: Anglais Texte intégral: Braz. j. infect. dis Thème du journal: Maladies transmissibles Année: 2020 Type: Article Pays d'affiliation: Brésil Institution/Pays d'affiliation: Universidade Federal de São Paulo/BR

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Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Infections à pneumocoques / Tumeurs Type d'étude: Etude d'étiologie / Etude d'incidence / Étude observationnelle / Étude pronostique / Facteurs de risque Limites du sujet: Enfant / Enfant d'âge préscolaire / Femelle / Humains / Bébé / Mâle Pays comme sujet: Amérique du Sud / Brésil langue: Anglais Texte intégral: Braz. j. infect. dis Thème du journal: Maladies transmissibles Année: 2020 Type: Article Pays d'affiliation: Brésil Institution/Pays d'affiliation: Universidade Federal de São Paulo/BR