Predictors and reference equations for augmentation index, an arterial stiffness marker, in healthy children and adolescents
Clinics
;
76: e2350, 2021. tab, graf
Article
Dans Anglais
| LILACS
| ID: biblio-1153985
ABSTRACT
OBJECTIVES:
To investigate predictors and propose reference equations for the augmentation index normalized to 75 bpm heart rate (AIx@75) in healthy children and adolescents.METHODS:
This was a cross-sectional, observational study involving 134 healthy children and adolescents aged 9 to 19 years old. Participants were categorized into child (n=53) and adolescent (n=81) groups, as well as into male (n=69) and female (n=65) groups. We evaluated AIx@75, vascular and hemodynamic parameters, anthropometric data, physical activity profile, and quality of life (Peds-QL4.0; physical, emotional, social and school domains).RESULTS:
The predictors of AIx@75 in the whole sample were age, peripheral diastolic blood pressure (pDBP), mean arterial pressure, pulse pressure amplification (PPA), systolic volume (SV), cardiac index (CI), and pulse wave velocity (PWV; R2=80.47%). In the male group, the predictors of AIx@75 were SV, CI, total vascular resistence (TVR), and PWV (R2=78.56%), while in the female group, they were pDBP, PPA, SV, and PWV (R2=82.45%). In the children, they were pDBP, PPA, SV, and PWV (R2=79.17%), while in the adolescents, they were body mass index, pDBP, PPA, SV, TVR, and PWV (R2=81.57%).CONCLUSION:
In the present study, we used a representative sample from Belo Horizonte to establish normality values of AIx@75. We also identified, for the first time, independent predictors of AIx@75 in healthy children and adolescents categorized by sex and age. Determining AIx@75 reference equations may facilitate the early diagnosis of preclinical atherosclerosis and allow an objective measure of the vascular effects of therapeutic interventions aimed at modifying cardiovascular risk factors.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Rigidité vasculaire
Type d'étude:
Etude d'étiologie
/
Étude observationnelle
/
Étude de prévalence
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Étude pronostique
/
Facteurs de risque
/
Étude de dépistage
Limites du sujet:
Adolescent
/
Adulte
/
Enfant
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Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Clinics
Thème du journal:
Médicament
Année:
2021
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais/BR
/
Programa de Pos-Graduacao em Ciencias da Saude, Faculdade Ciencias Medicas de Minas Gerais/BR
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