Streptozotocin-induced diabetes, bile-pancreatic secretion and insulo-pancreon-axis interaction / Streptozotocin-induced diabetes, bile-pancreatic secretion and insulo-pancreon-axis interaction.
Acta gastroenterol. latinoam
;
43(4): 294-300, 2013 Dec.
Article
Dans Espagnol
| LILACS, BINACIS
| ID: biblio-1157399
ABSTRACT
The present tests were undertaken in order to analyze in male Wistar rats the changes in the exocrine and endocrine pancreas and on the interactions that normally evolve in the insulo-pancreon-axis. To evaluate this by a single i.p. Boots secretin injection, glycemia (G), amylasemia (A) and lipasemia (L) were determined. In bile-pancreatic secretion, we analyzed, pre and post-secretin, the following parameters volume (V), bicarbonate output (BO), amylase output (AO) and lipase output (LO). Three groups of tests were done a) control (C); b) streptozotocin-treated non-diabetic-rats (St-ND) and c) streptozotocin-treated diabetic animals (St-D) which showed morning glycemia values higher than 16.0 mmol/l. Four months later, under Tiopental i.p anesthesia, a bile-pancreatic fistula was done. Following a 30 min basal period, Boots secretin (20 CU/kg) was i.p injected. Bile-pancreatic secretion put in evidence a significant fall of BO in both St-ND and St-D series. In controls, AO revealed a post-secretin increase of 160
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Indice:
LILAS (Amériques)
Sujet Principal:
Pancréas
/
Bile
/
Diabète expérimental
langue:
Espagnol
Texte intégral:
Acta gastroenterol. latinoam
Thème du journal:
Gastroentérologie
Année:
2013
Type:
Article
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