TNF-α-308 G/A variant may be associated with bipolar disorder in a Turkish population
Arch. Clin. Psychiatry (Impr.)
;
47(6): 176-179, Nov.Dec. 2020. tab
Article
Dans Anglais
|
LILACS-Express
| LILACS
| ID: biblio-1248761
ABSTRACT
ABSTRACT Background:
Tumor necrosis factor alpha (TNF-α) is a proinflammatory multifunctional cytokine produced by macrophages. A dysregulation of the immune system contribute to the pathogenesis of bipolar disorder (BD). In this study, we aimed to investigate the relationship between the TNF-α gene -308G/A promoter variant and the risk of BD.Methods:
A total of 104 BD patients and 94 healthy controls were enrolled in the study. Genomic DNA was isolated and TNF-α -308G/A variant was analyzed using PCR-RFLP method.Results:
TNF-α -308G/A variant GG genotype and G allele were more prevalent in BD patients compared to the controls (p = 0.002 and p = 0.017, respectively). The patients carrying GG genotype had a 5.927-fold higher risk of developing BD. Then, we divided patients into two groups as smokers and non-smokers. TNF-α -308G/A variant GA genotype was higher in non-smoker BD patients than smoker patients (p = 0.027). We found that TNF-α -308G/A AA genotype and A allele increased in smoker patients compared to non-smoker patients (p = 0.008, p = 0.002, respectively).Discussion:
Our results provided evidence that TNF-α -308G/A variant may contribute to development of BD in a Turkish cohort. In addition, this variant plays a relevant role in the smoker status of BD.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Type d'étude:
Facteurs de risque
langue:
Anglais
Texte intégral:
Arch. Clin. Psychiatry (Impr.)
Thème du journal:
Psychiatrie
Année:
2020
Type:
Article
Pays d'affiliation:
Turquie
Institution/Pays d'affiliation:
Bakirkoy Research and Training Hospital for Psychiatry, Neurology and Neurosurgery/TR
/
Gaziantep Univesity/TR
/
Hitit University/TR
/
Istanbul University/TR
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