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Estradiol prevented intestinal ischemia and reperfusion-induced changes in intestinal permeability and motility in male rats
Ricardo-da-Silva, Fernanda Yamamoto; Fantozzi, Evelyn Thaís; Rodrigues-Garbin, Sara; Domingos, Helori Vanni; Oliveira-Filho, Ricardo Martins; Vargaftig, Bernardo Boris; Riffo-Vasquez, Yanira; Breithaupt-Faloppa, Ana Cristina; Tavares-de-Lima, Wothan.
  • Ricardo-da-Silva, Fernanda Yamamoto; Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo. Instituto do Coracao (InCor). Laboratorio de Cirurgia Cardiovascular e Fisiopatologia da Circulacao (LIM-11). Sao Paulo. BR
  • Fantozzi, Evelyn Thaís; Instituto de Ciencias Biomedicas, Universidade de Sao Paulo. Departamento de Farmacologia. Sao Paulo. BR
  • Rodrigues-Garbin, Sara; Instituto de Ciencias Biomedicas, Universidade de Sao Paulo. Departamento de Farmacologia. Sao Paulo. BR
  • Domingos, Helori Vanni; Instituto de Ciencias Biomedicas, Universidade de Sao Paulo. Departamento de Farmacologia. Sao Paulo. BR
  • Oliveira-Filho, Ricardo Martins; Instituto de Ciencias Biomedicas, Universidade de Sao Paulo. Departamento de Farmacologia. Sao Paulo. BR
  • Vargaftig, Bernardo Boris; Instituto de Ciencias Biomedicas, Universidade de Sao Paulo. Departamento de Farmacologia. Sao Paulo. BR
  • Riffo-Vasquez, Yanira; Kings College London. Institute of Pharmaceutical Science. Sackler Institute of Pulmonary Pharmacology. GB
  • Breithaupt-Faloppa, Ana Cristina; Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo. Instituto do Coracao (InCor). Laboratorio de Cirurgia Cardiovascular e Fisiopatologia da Circulacao (LIM-11). Sao Paulo. BR
  • Tavares-de-Lima, Wothan; Instituto de Ciencias Biomedicas, Universidade de Sao Paulo. Departamento de Farmacologia. Sao Paulo. BR
Clinics ; 76: e2683, 2021. graf
Article Dans Anglais | LILACS | ID: biblio-1249591
ABSTRACT

OBJECTIVES:

Ischemia and reperfusion (I/R) in the intestine could lead to severe endothelial injury, compromising intestinal motility. Reportedly, estradiol can control local and systemic inflammation induced by I/R injury. Thus, we investigated the effects of estradiol treatment on local repercussions in an intestinal I/R model.

METHODS:

Rats were subjected to ischemia via the occlusion of the superior mesenteric artery (45 min) followed by reperfusion (2h). Thirty minutes after ischemia induction (E30), 17β-estradiol (E2) was administered as a single dose (280 μg/kg, intravenous). Sham-operated animals were used as controls.

RESULTS:

I/R injury decreased intestinal motility and increased intestinal permeability, accompanied by reduced mesenteric endothelial nitric oxide synthase (eNOS) and endothelin (ET) protein expression. Additionally, the levels of serum injury markers and inflammatory mediators were elevated. Estradiol treatment improved intestinal motility, reduced intestinal permeability, and increased eNOS and ET expression. Levels of injury markers and inflammatory mediators were also reduced following estradiol treatment.

CONCLUSION:

Collectively, our findings indicate that estradiol treatment can modulate the deleterious intestinal effects of I/R injury. Thus, estradiol mediates the improvement in gut barrier functions and prevents intestinal dysfunction, which may reduce the systemic inflammatory response.
Sujets)


Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Lésion d'ischémie-reperfusion / Oestradiol Type d'étude: Étude pronostique Limites du sujet: Animaux langue: Anglais Texte intégral: Clinics Thème du journal: Médicament Année: 2021 Type: Article Pays d'affiliation: Brésil / Royaume-Uni Institution/Pays d'affiliation: Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo/BR / Instituto de Ciencias Biomedicas, Universidade de Sao Paulo/BR / Kings College London/GB

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Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Lésion d'ischémie-reperfusion / Oestradiol Type d'étude: Étude pronostique Limites du sujet: Animaux langue: Anglais Texte intégral: Clinics Thème du journal: Médicament Année: 2021 Type: Article Pays d'affiliation: Brésil / Royaume-Uni Institution/Pays d'affiliation: Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo/BR / Instituto de Ciencias Biomedicas, Universidade de Sao Paulo/BR / Kings College London/GB