Antigenotoxic Effect of Ferulic Acid in 7;12-Dimethyl Beza (A) - Anthracene (DMBA) Induced Genotoxicity
Afr. J. Tradit. Complement. Altern. Med. (Online)
;
5(1): 32-38, 2007.
Article
Dans Anglais
| AIM
| ID: biblio-1256191
ABSTRACT
The antigenotoxic effect of ferulic acid was carried out by evaluating the cytogenetic markers; the micronuclei frequency and chromosomal aberrations; in the bone marrow of hamsters in 7;12dimethylbenz(a)anthracene (DMBA) induced genotoxicity. Genotoxicity was induced in experimental hamsters by single intraperitoneal injection of DMBA (30mg kg-1 b.w). Pretreatment of ferulic acid orally at a dose of 40mg kg-1 b.w for five days significantly reduced the frequency of micronucleated polychromatic erythrocytes (MnPCEs) and the percentage of chromosomal aberrations in hamster's bone marrow. Our results thus suggest that ferulic acid has potent antigenotoxic effect in DMBA induced genotoxicity in golden Syrian hamsters
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Indice:
AIM (Afrique)
Sujet Principal:
Peroxydation lipidique
/
Aberrations des chromosomes
/
Antioxydants
langue:
Anglais
Texte intégral:
Afr. J. Tradit. Complement. Altern. Med. (Online)
Année:
2007
Type:
Article
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