Assessment of the Efficacy of Ankaferd Blood Stopper on the Prevention of Postoperative Pericardial Adhesions : Cardiovascular Topic

ABSTRACT

Objectives: Ankaferd has been used as a blood-stopping agent and it may also have an anti-inflammatory effect. We investigated the efficacy of Ankaferd in preventing postoperative pericardial adhesions in an experimental rabbit model. Methods: Sixteen New Zealand white rabbits were used and categorised into two groups an Ankaferd and a control group. The Ankaferd group of rabbits was treated with a sponge impregnated with Ankaferd solution; which was applied over the abraded epicardium. A sponge impregnated with 0.9 isotonic NaCl solution was applied to the control group using the same protocol. Scores for adhesion and visibility of coronary vessels were graded by macroscopic examination; and pericardial tissues were analysed microscopically in terms of inflammation and fibrosis. Results: In the Ankaferd group; the adhesion scores were significantly higher than in the control group (p = 0.007).When the groups were compared according to the prevalence of fibrosis and degree of inflammation; the Ankaferd group was found to be statistically significantly different from the control group in terms of prevalence of fibrosis (p = 0.028). Conclusion: Topical application of Ankaferd to prevent postoperative pericardial adhesions increased adhesion and fibrosis scores