Preliminary appraisal of a WHO-recommended multiple drug regimen in paucibacillary leprosy patients in Malawi
Int. j. lepr. other mycobact. dis
;
56(3): 408-17, 1988.
Article
Dans Anglais
| AIM
| ID: biblio-1263007
ABSTRACT
A study was undertaken within the framework of the LEPRA Evaluation Project and the LEPRA Control Project in Malawi (Central Africa) to study the incidence rates of type 1 reactions and of relapses in paucibacillary leprosy patients treated with the current World Health Organization-recommended multiple drug regimen (WHO/MDT). Of 503 patients recruited into the study; 488 were reviewed at the end of treatment and 480 have now been followed for 1 year after completion of treatment. At the end of treatment the skin lesions had completely disappeared in 27.4 percent ; but were judged to be still active in 4.3 percent . During the follow-up period two patients were found with new active skin lesions; giving a relapse rate of 4.17 (2 of 480) per 1000 person years during the first year after completion of WHO/MDT (95 percent confidence interval 1.14 to 15.06 per 1000 person years). The incidence rate of marked type 1 reaction (renewed inflammation in previously inactive lesions) during the first year after completion of WHO/MDT was 47.8 per 1000 person years in self-reporting patients but zero in patients identified by active case finding. Data are presented which suggest that the incidence rate of late type 1 reactions is closely related to the classification and stage of the disease at detection
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Indice:
AIM (Afrique)
Type d'étude:
Étude pronostique
langue:
Anglais
Texte intégral:
Int. j. lepr. other mycobact. dis
Année:
1988
Type:
Article
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