Haematopoietic stem cell transplantation in South Africa: Current limitations and future perspectives
S. Afr. med. j. (Online)
;
109(8): 46-52, 2019.
Article
Dans Anglais
| AIM
| ID: biblio-1271229
ABSTRACT
The growing need for haematopoietic stem cell transplantation (HSCT) is reflected in the increasing number of transplants performed globally each year. HSCT provides life-changing and potentially curative therapy for a range of pathologies including haematological malignancies; other indications include certain congenital and acquired disorders of the haematopoietic system, autoimmune conditions and hereditary diseases. The primary goals of HSCT are either to replace haematopoietic stem and progenitor cells (HSPC) following myeloablative chemotherapy or to cure the original pathology with allogeneic HSPCs. Success depends on optimal outcomes at various stages of the procedure including mobilisation of marrow stem/progenitor cells for harvesting from the patient or donor, long-term and sustainable engraftment of these cells in the recipient, and prevention of graft-versus-host disease in the case of allogeneic HSCT. Challenges in South Africa include high cost, limited infrastructure and lack of appropriately trained staff, as well as limitations in securing suitable haematopoietic stem cell donors. This review aims to provide an overview of HSCT and some of the challenges that are faced in the South African context
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Indice:
AIM (Afrique)
Sujet Principal:
République d'Afrique du Sud
/
Transplantation de cellules souches
/
Current procedural terminology (USA)
/
Niche de cellules souches
/
Prévision
/
Système hématopoïétique
Type d'étude:
Étude pronostique
Pays comme sujet:
Afrique
langue:
Anglais
Texte intégral:
S. Afr. med. j. (Online)
Année:
2019
Type:
Article
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