Epidemiological characteristics of hemophilia in the pre-primary prophylaxis era: a historical cohort
Clin. biomed. res
;
41(1): 1-5, 2021. tab
Article
Dans Anglais
| LILACS
| ID: biblio-1280782
ABSTRACT
Introduction:
Epidemiological studies on hemophilia in the Brazilian population are historically scarce. Despite the continuous effort made by the National Program of Inherited Bleeding Disorders to map this condition, little information is available, especially on the period prior to program conception. Therefore, the present study aims to assess the epidemiological, serological, and clinical characteristics of patients with hemophilia in the state of Rio Grande do Sul, Brazil.Methods:
A total of 455 patients had their medical records reviewed from January 1, 2003 to December 31, 2007.Results:
We observed a remarkable prevalence of hepatitis C virus (HCV) infection in patients with both hemophilia A and B, and this prevalence significantly increased along with age (p < 0.001). No positive anti-HCV results were observed among children younger than 5 years old. There was a significant correlation between the severity of hemophilia and the number of arthropathies in all age categories. Considering the presence of inhibitors, a significant difference was observed between age groups, as older patients had higher inhibitor titers. There was a significant correlation between mean coagulation factor consumption and the number of arthropathies in patients over 5 years old.Conclusions:
This profile analysis of patients with hemophilia reflects a gradual improvement in treatment safety and efficiency, as well as the need for continued investment in this population. (AU)
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Hépatite C
/
Hémophilie A
Type d'étude:
Etude d'étiologie
/
Etude d'incidence
/
Étude observationnelle
/
Facteurs de risque
Limites du sujet:
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Clin. biomed. res
Thème du journal:
Médicament
Année:
2021
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Hemocentro do Estado do Rio Grande do Sul/BR
/
Hospital de Clínicas de Porto Alegre/BR
/
Universidade Estadual do Rio Grande do Sul/BR
/
Universidade Federal do Rio Grande do Sul/BR
/
Universidade de Caxias do Sul/BR
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