Perspectives of bilateral thoracic sympathectomy for treatment of heart failure
Clinics
;
76: e3248, 2021. graf
Article
Dans Anglais
| LILACS
| ID: biblio-1286075
ABSTRACT
Surgical neuromodulation therapies are still considered a last resort when standard therapies have failed for patients with progressive heart failure (HF). Although a number of experimental studies have provided robust evidence of its effectiveness, the lack of strong clinical evidence discourages practitioners. Thoracic unilateral sympathectomy has been extensively studied and has failed to show significant clinical improvement in HF patients. Most recently, bilateral sympathectomy effect was associated with a high degree of success in HF models, opening the perspective to be investigated in randomized controlled clinical trials. In addition, a series of clinical trials showed that bilateral sympathectomy was associated with a decreased risk of sudden death, which is an important outcome in patients with HF. These aspects indicates that bilateral sympathectomy could be an important alternative in the treatment of HF wherein pharmacological treatment barely reaches the target dose.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Procédures de chirurgie thoracique
/
Défaillance cardiaque
/
Hyperhidrose
Type d'étude:
Essai clinique contrôlé
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Clinics
Thème du journal:
Médicament
Année:
2021
Type:
Article
Pays d'affiliation:
Brésil
/
Suède
Institution/Pays d'affiliation:
Karolinska Institutet/SE
/
Universidade de Sao Paulo/BR
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