Gut microbiota in Mexican patients with common variable immunodeficiency
Gac. méd. Méx
;
155(5): 447-452, Sep.-Oct. 2019. tab, graf
Article
Dans Anglais
| LILACS
| ID: biblio-1286541
ABSTRACT
Introduction:
Common variable immunodeficiency (CVID) is the main symptomatic primary immunodeficiency and is associated with complex immune disorders. Gut microbiota interacts closely with the immune system, and intestinal dysbiosis is related to multiple diseases.Objective:
To describe for the first time the composition of gut microbiota in Mexican patients with CVID.Methods:
Fecal samples from five patients with CVID were collected and massive sequencing of the V3-V4 region of 16S rRNA gene was carried out using illumina technology.Results:
Bacterial relative abundance was observed at all taxonomic levels. Firmicutes, Actinobacteria and Verrucomicrobia were the predominant phyla. The Clostridia class and the Clostridial order were the most common in their respective taxon; the Ruminococcaceae family predominated. A total of 166 genera were reported, with the most abundant being Faecalibacterium. Five species were identified, but only Bifidobacterium longum was present in all patients.Conclusions:
Unlike healthy subjects' gut microbiota, where Firmicutes and Bacteroidetes predominate, the microbiota of the patients with CVID considered in this study was abundant in Firmicutes, Actinobacteria and Verrucomicrobia. The low presence of Bacteroidetes and high abundance of Firmicutes might indicate the existence of intestinal dysbiosis in these patients.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Déficit immunitaire commun variable
/
Microbiome gastro-intestinal
Type d'étude:
Étude pronostique
Limites du sujet:
Adulte
/
Humains
Pays comme sujet:
Mexico
langue:
Anglais
Texte intégral:
Gac. méd. Méx
Thème du journal:
Médicament
Année:
2019
Type:
Article
Pays d'affiliation:
Mexique
Institution/Pays d'affiliation:
Instituto Mexicano del Seguro Social/MX
/
Universidad Juárez del Estado de Durango/MX
/
Universidad Nacional Autónoma de México/MX
/
Universidad de Guadalajara/MX
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