Cannabis and the exocannabinoid and endocannabinoid systems. Their use and controversies
Gac. méd. Méx
;
155(5): 471-474, Sep.-Oct. 2019. tab
Article
Dans Anglais
| LILACS
| ID: biblio-1286545
ABSTRACT
Cannabis (marijuana) is one of the most consumed psychoactive substances in the world. The term marijuana is of Mexican origin. The primary cannabinoids that have been studied to date include cannabidiol and delta-9-tetrahydrocannabinol, which is responsible for most cannabis physical and psychotropic effects. Recently, the endocannabinoid system was discovered, which is made up of receptors, ligands and enzymes that are widely expressed in the brain and its periphery, where they act to maintain balance in several homeostatic processes. Exogenous cannabinoids or naturally-occurring phytocannabinoids interact with the endocannabinoid system. Marijuana must be processed in a laboratory to extract tetrahydrocannabinol and leave cannabidiol, which is the product that can be marketed. Some studies suggest cannabidiol has great potential for therapeutic use as an agent with antiepileptic, analgesic, anxiolytic, antipsychotic, anti-inflammatory and neuroprotective properties; however, the findings on cannabinoids efficacy and cannabis-based medications tolerability-safety for some conditions are inconsistent. More scientific evidence is required in order to generate recommendations on the use of medicinal cannabis.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Cannabidiol
/
Endocannabinoïdes
/
Marijuana médicale
Type d'étude:
Guide de pratique
Limites du sujet:
Animaux
/
Humains
langue:
Anglais
Texte intégral:
Gac. méd. Méx
Thème du journal:
Médicament
Année:
2019
Type:
Article
Pays d'affiliation:
Mexique
Institution/Pays d'affiliation:
Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado/MX
/
Universidad de Colima/MX
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