Safety and efficacy of "on-demand" tramadol in patients with premature ejaculation: an updated meta-analysis
Int. braz. j. urol
;
47(5): 921-934, Sept.-Oct. 2021. tab, graf
Article
Dans Anglais
| LILACS
| ID: biblio-1286794
ABSTRACT
ABSTRACT Introduction:
Tramadol has been used for the treatment of premature ejaculation, however, the studies published for the same are not well designed. The primary objective of this study was to explore the literature pertaining to the use of tramadol in patients with PE to determine its safety and efficacy in this population. Materials andemethods:
Systematic literature search of various electronic databases was conducted to include all the randomized studies and quasi-randomized studies. Standard PRISMA (Preferred reporting Items for Systematic reviews and Meta-analysis) guidelines were pursued for this review and study protocol was registered with PROSPERO (CRD42019123381).Results:
Out of 9 studies included in this review, 5 were randomized controlled trials, and rests of the 4 studies were quasi-randomized studies. Tramadol resulted in significantly higher improvement of IELT with the mean difference (MD) of 139.6 seconds and confidence interval (CI) 106.5-172.6 seconds with a p-value of p <0.00001. All dosages except 25mg fared well as compared to placebo. Tramadol fared better than placebo at 1 month, 2 months, and 3 months after initiation of therapy as compared to the placebo. Tramadol group had reported a significantly higher number of adverse events with treatment as compared to placebo but none of them were serious.Conclusion:
Tramadol appears to be an effective drug for the management of PE with a low propensity for serious adverse events. However, evidence obtained from this study is of low to moderate quality. Furthermore, effective dose and duration of therapy remain elusive.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Tramadol
/
Éjaculation précoce
Type d'étude:
Essai clinique contrôlé
/
Guide de pratique
/
Revues systématiques évaluées
Limites du sujet:
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Int. braz. j. urol
Thème du journal:
Urologie
Année:
2021
Type:
Article
Pays d'affiliation:
Inde
Institution/Pays d'affiliation:
PGIMER/IN
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