Epidemiological evaluation and survival of children with acute myeloid leukemia
J. pediatr. (Rio J.)
;
97(2): 204-210, Mar.-Apr. 2021. tab, graf
Article
Dans Anglais
| LILACS
| ID: biblio-1287020
ABSTRACT
Abstract Objective:
This study aims to describe the epidemiological characteristics and survival rates of children with acute myeloid leukemia treated in hospitals in southern Brazil and compare them with international data.Methods:
A multicenter cohort study was conducted with retrospective data collection of all new patients with acute myeloid leukemia under 18 treated at five referral centers in pediatric hematology-oncology in southern Brazil between January 2005 and December 2015.Results:
Of the 149 patients with acute myeloid leukemia, 63.0% (n = 94) were male. The median age at diagnosis was 10.5 years (range 0-18 years) and 40.3% (n = 60) had a white blood cell count below 50,000/mm2. The most common Franco-American-British (FAB) subtype was M3 (n = 43, 28.9%). Nine (6.0%) patients had central nervous system disease. In M3 patients, overall survival (OS) was 69.2% and 3-year event-free survival was 67.7%; in non-M3 patients, these rates were 45.3% and 36.7%, respectively. In non-M3 patients, OS was significantly different between transplanted (61.8%) and non-transplanted (38.2%) patients (p = 0.031).Conclusions:
These results show a higher prevalence of the Franco-American-British M3 subtype than that reported in the international literature, as well as a decreased OS compared with that of developed countries. Further multicenter Brazilian studies with a larger sample size are encouraged to better understand the characteristics of acute myeloid leukemia, and to improve the treatment and prognosis in this population.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Leucémie aigüe myéloïde
Type d'étude:
Etude d'étiologie
/
Etude d'incidence
/
Étude observationnelle
/
Étude pronostique
/
Facteurs de risque
Limites du sujet:
Adolescent
/
Enfant
/
Enfant d'âge préscolaire
/
Humains
/
Bébé
/
Mâle
/
Nouveau-né
Pays comme sujet:
Amérique du Sud
/
Brésil
langue:
Anglais
Texte intégral:
J. pediatr. (Rio J.)
Thème du journal:
Pédiatrie
Année:
2021
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Hospital São Vicente de Paulo/BR
/
Hospital da Criança Santo Antônio/BR
/
Hospital de Clínicas de Porto Alegre (HCPA)/BR
/
Universidade Federal de Ciências da Saúde de Porto Alegre/BR
/
Universidade Federal de Pelotas (UFPEL)/BR
/
Universidade Federal do Rio Grande do Sul (UFRGS)/BR
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