Mechanism of action of glycyrrhizin against Plasmodium falciparum
Mem. Inst. Oswaldo Cruz
; 116: e210084, 2021. tab, graf
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| ID: biblio-1287344
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BR1.1
ABSTRACT
Extracts of the plant Glycyrrhiza glabra (licorice) are used in traditional medicine to treat malaria. The main active components are the saponin glycyrrhizin (GLR) and its active metabolite glycyrrhetinic acid (GA) which both display activities against Plasmodium falciparum. We have identified three main mechanisms at the origin of their anti-plasmodial activity (i) drug-induced disorganisation of membrane lipid rafts, (ii) blockade of the alarmin protein HMGB1 and (iii) potential inhibition of the detoxifying enzyme glyoxalase 1 (GLO-1) considered as an important drug target for malaria. Our analysis shed light on the mechanism of action of GLR against P. falciparum.
Mots clés
Texte intégral:
1
Indice:
LILACS
Sujet Principal:
Triterpènes
/
Glycyrrhiza
langue:
En
Texte intégral:
Mem. Inst. Oswaldo Cruz
Thème du journal:
MEDICINA TROPICAL
/
PARASITOLOGIA
Année:
2021
Type:
Article