6-hydroxydopamine and ovariectomy has no effect on heart rate variability parameters of females
Clinics
; 76: e3175, 2021. graf
Article
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| LILACS
| ID: biblio-1339705
Responsable en Bibliothèque :
BR1.1
ABSTRACT
OBJECTIVES:
In addition to the classic motor symptoms of Parkinson's disease (PD), patients also present with non-motor symptoms, such as autonomic dysfunction, which is present in almost 90% of patients with PD, affecting the quality of life and mortality. Regarding sex differences in prevalence and presentation, there is increasing concern about how sex affects autonomic dysfunction. However, there are no previous data on autonomic cardiac function in females after 6-hydroxydopamine (6-OHDA) striatal injection.METHODS:
Wistar female rats were ovariectomized. After 20 days, the animals received bilateral injections of 6-OHDA (total dose per animal 48 µg) or a vehicle solution in the striatum. Thirty days after 6-OHDA injection, subcutaneous electrodes were implanted for electrocardiogram (ECG) recording. Ten days after electrode implantation, ECG signals were recorded. Analyses of heart rate variability (HRV) parameters were performed, and the 6-OHDA lesion was confirmed by analyzing the number of tyrosine hydroxylase-positive neurons in the substantia nigra pars compacta (SNpc).RESULTS:
A high dose of 6-OHDA did not affect HRV of females, independent of ovariectomy. As expected, ovariectomy did not affect HRV or lesions in the SNpc after 6-OHDA injection.CONCLUSIONS:
We suggest that females with 6-OHDA present with cardioprotection, independent of ovarian hormones, which could be related to female vagal predominance.
Texte intégral:
1
Indice:
LILACS
Sujet Principal:
Qualité de vie
Type d'étude:
Risk_factors_studies
Limites du sujet:
Animals
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Female
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Humans
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Male
langue:
En
Texte intégral:
Clinics
Thème du journal:
MEDICINA
Année:
2021
Type:
Article