Late vitamin K deficiency bleeding in infants: five-year prospective study
J. pediatr. (Rio J.)
;
97(5): 514-519, Sept.-Oct. 2021. tab, graf
Article
Dans Anglais
| LILACS
| ID: biblio-1340159
ABSTRACT
Abstract Objective:
To study the presenting clinical and demographic features, risk factors, and outcome of infants with late vitamin K deficiency bleeding.Methods:
Over a 5-year study period, the presenting clinical features and outcome of all 47 infants observed aged less than 6 months, who were diagnosed with late-onset primary and secondary VKDB by detailed history, physical examination, and laboratory findings were evaluated. Confirmed primary late VKDB was diagnosed when no cause other than breastfeeding could be found, while in the secondary subtype additional risk factors compromising the vitamin K effect were diagnosed.Results:
Secondary late VKDB (83%, 39 patients) was more common than the primary subtype. The mean age of patients was 10.50 ± 5.75 and 9.74 ± 6.04 weeks in primary and secondary VKDB subtypes, respectively, and the age of infants did not have a significant difference (> 0.05). The male to female ratio was 2.131. The residency, place and mode of delivery, gestational age, and types of feeding of patients did not have a significant difference between VKDB subtypes. The skin and gastrointestinal tract (GIT) (40.4%) followed by intracranial hemorrhage (ICH) (32%), were common sites of bleeding. Neurological complications were seen in 21% of patients; however, lethality was 23%, and the outcome of patients did not have a significant difference (p > 0.05) between VKDB subtypes.Conclusion:
Secondary late VKDB is more common than the primary subtypes, and late VKDB is still a serious disease in developing countries, including Iraq, when vitamin K prophylaxis isn't routinely used at birth.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Saignement dû au déficit en vitamine K
Type d'étude:
Étude observationnelle
/
Facteurs de risque
Limites du sujet:
Femelle
/
Humains
/
Bébé
/
Mâle
/
Nouveau-né
langue:
Anglais
Texte intégral:
J. pediatr. (Rio J.)
Thème du journal:
Pédiatrie
Année:
2021
Type:
Article
Pays d'affiliation:
Iraq
Institution/Pays d'affiliation:
University of Misan/IQ
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