Cardiomyopathy and cardiac function in fetuses and newborns of diabetic mothers
J. pediatr. (Rio J.)
;
97(5): 520-524, Sept.-Oct. 2021. tab
Article
Dans Anglais
| LILACS
| ID: biblio-1340162
ABSTRACT
Abstract Objective:
To evaluate cardiac function and structural changes in children of diabetic mothers in the fetal and neonatal period using Doppler-echocardiographic data.Method:
A prospective, descriptive observational study conducted in a private and tertiary care service for high-risk pregnant women. It included 48 children of mothers with gestational diabetes mellitus (GDM) considered clinically compensated during pregnancy, with a single fetus and absence of malformations. Myocardial thickness, shortening fraction, left ventricular (LVMPI) and right ventricular (RVMPI) myocardial performance index, and mitral and tricuspid valve E/A ratio were evaluated in 96 echocardiographic exams with Doppler.Results:
The hypertrophic cardiomyopathy was 29% vs 6% p = 0.006 in the prenatal and postnatal periods respectively. The shortening fraction was 0% vs 6% p = 0.242 in the fetuses and newborns respectively. The myocardial performance index of the right ventricle was 12% vs 54% p ≤ 0.001, and on the left ventricle 27% vs 60% p = 0.001 in the prenatal and postnatal periods respectively. The ratio of mitral valve E/A waves was 6% vs 50% p ≤ 0.001 and the ratio of tricuspid valve E/A waves was 0% vs 27% p 0.001 in the fetuses and newborns respectively.Conclusion:
A decrease in the rate of myocardial hypertrophy and changes in cardiac function parameters were observed in the fetal and neonatal periods.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Diabète gestationnel
/
Cardiomyopathies
Type d'étude:
Etude diagnostique
/
Étude observationnelle
/
Facteurs de risque
Limites du sujet:
Enfant
/
Femelle
/
Humains
/
Nouveau-né
/
Grossesse
langue:
Anglais
Texte intégral:
J. pediatr. (Rio J.)
Thème du journal:
Pédiatrie
Année:
2021
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
UNIMED Hospital Center/BR
/
Universidade Federal de São Paulo (UNIFESP)/BR
/
Universidade da Região de Joinville (UNIVILLE)/BR
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