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Growth hormone-releasing hormone-secreting pulmonary neuroendocrine tumor associated with pituitary hyperplasia and somatotropinoma
Lamback, Elisa B.; Henriques, Daniel G.; Vazquez-Borrego, Mari C.; Lima, Carlos H. de Azeredo; Kasuki, Leandro; Luque, Raul M.; Chimelli, Leila; Gadelha, Mônica R..
  • Lamback, Elisa B.; Hospital Universitário Clementino Fraga Filho. Faculdade de Medicina. Divisão de Endocrinologia. Rio de Janeiro. BR
  • Henriques, Daniel G.; Hospital Universitário Clementino Fraga Filho. Faculdade de Medicina. Divisão de Endocrinologia. Rio de Janeiro. BR
  • Vazquez-Borrego, Mari C.; Instituto Maimónides de Pesquisas Biomédicas de Córdoba. Córdoba. ES
  • Lima, Carlos H. de Azeredo; Instituto Estadual do Cérebro Paulo Niemeyer. Laboratório de Neuropatologia e Genética Molecular. Rio de Janeiro. BR
  • Kasuki, Leandro; Hospital Universitário Clementino Fraga Filho. Faculdade de Medicina. Divisão de Endocrinologia. Rio de Janeiro. BR
  • Luque, Raul M.; Instituto Maimónides de Pesquisas Biomédicas de Córdoba. Córdoba. ES
  • Chimelli, Leila; Instituto Estadual do Cérebro Paulo Niemeyer. Laboratório de Neuropatologia e Genética Molecular. Rio de Janeiro. BR
  • Gadelha, Mônica R.; Hospital Universitário Clementino Fraga Filho. Faculdade de Medicina. Divisão de Endocrinologia. Rio de Janeiro. BR
Arch. endocrinol. metab. (Online) ; 65(5): 648-663, 2021. tab, graf
Article Dans Anglais | LILACS | ID: biblio-1345192
ABSTRACT
SUMMARY Acromegaly caused by ectopic growth hormone-releasing hormone (GHRH)-secreting tumor is exceedingly rare. We report a case of acromegaly secondary to GHRH secretion by an incidentally diagnosed pulmonary neuroendocrine tumor (NET) and review 47 similar cases in literature. A 22-year-old male patient presented with symptoms of pituitary apoplexy. Magnetic resonance imaging (MRI) showed apoplexy of a pituitary adenoma. Routinely prior to surgery, a chest radiography was performed which revealed a mass in the left lung. During investigation, the patient was diagnosed with metastatic GHRH-secreting pulmonary NET. In retrospect, it was noted that the patient had pituitary hyperplasia 20 months prior to the MRI which showed the presence of a pituitary adenoma. The histological findings confirmed somatotroph hyperplasia adjacent to somatotropinoma. This case suggests that GHRH secretion can be associated with pituitary hyperplasia, which may be followed by pituitary adenoma formation.
Sujets)

Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Tumeurs de l'hypophyse / Acromégalie / Adénomes / Carcinome neuroendocrine Type d'étude: Facteurs de risque Limites du sujet: Adulte / Humains / Mâle langue: Anglais Texte intégral: Arch. endocrinol. metab. (Online) Thème du journal: Endocrinologie / Métabolisme Année: 2021 Type: Article Pays d'affiliation: Brésil / Espagne Institution/Pays d'affiliation: Hospital Universitário Clementino Fraga Filho/BR / Instituto Estadual do Cérebro Paulo Niemeyer/BR / Instituto Maimónides de Pesquisas Biomédicas de Córdoba/ES

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Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Tumeurs de l'hypophyse / Acromégalie / Adénomes / Carcinome neuroendocrine Type d'étude: Facteurs de risque Limites du sujet: Adulte / Humains / Mâle langue: Anglais Texte intégral: Arch. endocrinol. metab. (Online) Thème du journal: Endocrinologie / Métabolisme Année: 2021 Type: Article Pays d'affiliation: Brésil / Espagne Institution/Pays d'affiliation: Hospital Universitário Clementino Fraga Filho/BR / Instituto Estadual do Cérebro Paulo Niemeyer/BR / Instituto Maimónides de Pesquisas Biomédicas de Córdoba/ES