The Important Role of TMPRSS2 Gene in Covid-19 and Prostate Cancer: In Silico Approach
Braz. arch. biol. technol
;
64: e21200785, 2021. tab, graf
Article
Dans Anglais
|
LILACS-Express
| LILACS
| ID: biblio-1350264
ABSTRACT
Abstract Some studies have discovered a connection between prostate cancer and COVID-19. In this study, we evaluated the link between prostate cancer and COVID-19, contributing to elucidate the connection between TMPRSS2 and ACE2. We discovered 209 number of variants in TMPRSS2 gene, and 110 variants represent EA populations and 99 of them represent AA populations. Moreover, we found 23 suspected missense and 3 unknown variants. Then, linked genes to TMPRSS2 and ACE2 were found in our study. We investigated the expression level of TMPRSS2 and the results showed that it was very high in the prostate, colon, lung, kidney, and saliva-secreting gland. Also, the important role of the AR gene was revealed in addition to other oncogenes and tumor suppressor genes for prostate cancer by KEGG Pathway analysis. In conclusion, these results can highlight several molecular mechanisms of SARS-CoV-2, and also TMPRSS2, ACE2, and AR connection explains the high expression level of AR gene found in the male lung.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
langue:
Anglais
Texte intégral:
Braz. arch. biol. technol
Thème du journal:
Biologie
Année:
2021
Type:
Article
Pays d'affiliation:
Turquie
Institution/Pays d'affiliation:
Abant Izzet Baysal University/TR
/
Taksim Education and Research Hospital/TR
/
University of Health Sciences/TR
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