Cost-effectiveness of the regimen proposed by the International Consortium on Acute Promyelocytic Leukemia for the treatment of newly diagnosed patients with Acute Promyelocytic Leukemia
Hematol., Transfus. Cell Ther. (Impr.)
;
43(4): 476-481, Oct.-Dec. 2021. tab, ilus
Article
Dans Anglais
| LILACS
| ID: biblio-1350816
ABSTRACT
ABSTRACT Introduction:
We performed cost-effectiveness and cost-utility analyses of the modified International Consortium on Acute Promyelocytic Leukemia protocol in Mexico for the treatment of acute promyelocytic leukemia Acute Promyelocytic Leukemia.Methods:
We performed a three-state Markovanalysis:
stable disease (first line complete response [CR]), disease event (relapse, second line response and CR) and death. The modified IC-APL protocol is composed of three phases induction, consolidation and maintenance. Cost and outcomes were used to calculate incremental cost-effectiveness ratios (ICERs); quality-adjusted life-years were used to calculate incremental cost-utility ratios (ICURs).Results:
The CR was achieved in 18 patients (90%), treated with the IC-APL protocol as the first-line option; one patient (5%) died in induction, another one never achieved CR (5%); of the 18 patients that achieved CR, 1 relapsed (5.5%). The median treatment cost of the IC-APL protocol was $21,523 USD. The average life-year in our study was 7.8 years, while the average quality-adjusted life-year (QALY) was 6.1 years. When comparing the ICER between the IC-APL and the all-trans retinoic acid (ATRA) plus arsenic trioxide (ATO) protocols, we found the different costs of $6497, $19,133 and $17,123 USD in Italy, the USA and Canada, respectively. In relation to the ICUR, we found the different costs to be $13,955 and $11,979 USD in the USA and Canada, respectively.Conclusion:
Taking into account the similar response rates, lower cost and easy access to the modified IC-APL regimen, we consider it a cost-effective and cost-utility protocol, deeming it the treatment of choice for our population.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Leucémie aiguë promyélocytaire
Type d'étude:
Etude diagnostique
/
Guide de pratique
/
Évaluation en économique de la santé
Limites du sujet:
Adolescent
/
Adulte
/
Adulte très âgé
/
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Hematol., Transfus. Cell Ther. (Impr.)
Thème du journal:
Hematologia
/
TransfusÆo de Sangue
Année:
2021
Type:
Article
Pays d'affiliation:
Mexique
Institution/Pays d'affiliation:
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán/MX
/
Instituto Politecnico Nacional/MX
/
Universidad Anáhuac México Norte/MX
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