Decreased ovarian reserve and ovarian morphological alterations in female rat offspring exposed to a ketogenic maternal diet
Rev. Assoc. Med. Bras. (1992, Impr.)
;
67(10): 1415-1420, Oct. 2021. graf
Article
Dans Anglais
| LILACS
| ID: biblio-1351432
ABSTRACT
SUMMARY OBJECTIVE:
This study evaluates the effects of a ketogenic diet on morphology and follicle reserve.METHOD:
Sixteen Sprague-Dawley rats were randomized into two groups standard diet group (n=8) and ketogenic diet group (n=8). Rats were time mated. Dams were permitted to deliver spontaneously. The animals were monitored for the onset of puberty. All the rats were weighed and anesthetized, serum anti-Müllerian hormone level was measured, and the oviducts were removed. The morphological characteristics of follicles were determined and total ovarian volumes were calculated.RESULTS:
The mean ovarian volume was statistically significantly lower in the ketogenic diet group compared to the standard diet group (14.41±0.99 mm3 versus 18.89±1.28 mm3) (p=0.000). The mean number of antral follicles was 13.63±1.80 in the standard diet group and 4.462±0.760 in the ketogenic diet group. The mean ovarian weight of the ketogenic diet group was significantly lower than that of the standard diet group (0.42±0.06 g versus 0.815±107 g). The mean anti-Müllerian hormone levels were significantly higher in the standard diet group compared to the ketogenic diet group (1.023±4.75 ng/mL versus 0.69±0.07 ng/mL) (p=0.000). The mean percentage of staining of Ki-67 was 35.28±4.75 in the standard diet group and 16.98±3.33 in the ketogenic diet group (p=0.000).CONCLUSION:
Maternal ketogenic diet reduces ovarian follicular reserve in female offspring and has important implications for maintaining reproductive potential at a population level.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Régime cétogène
/
Réserve ovarienne
Type d'étude:
Essai clinique contrôlé
Limites du sujet:
Animaux
/
Femelle
/
Humains
langue:
Anglais
Texte intégral:
Rev. Assoc. Med. Bras. (1992, Impr.)
Thème du journal:
EducaÆo em Sa£de
/
GestÆo do Conhecimento para a Pesquisa em Sa£de
/
Médicament
Année:
2021
Type:
Article
Pays d'affiliation:
Turquie
Institution/Pays d'affiliation:
Erciyes University/TR
/
Private Tatvan Can Hospital/TR
/
Sakarya University/TR
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