Heterogeneous trajectories in schizophrenia: insights from neurodevelopment and neuroprogression models
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
;
44(1): 74-80, Jan.-Feb. 2022. graf
Article
Dans Anglais
|
LILACS-Express
| LILACS
| ID: biblio-1360176
ABSTRACT
The notion that schizophrenia is a neuroprogressive disorder is based on clinical perception of cumulative impairments over time and is supported by neuroimaging and biomarker research. Nevertheless, increasing evidence has indicated that schizophrenia first emerges as a neurodevelopmental disorder that could follow various pathways, some of them neuroprogressive. The objective of this review is to revisit basic research on cognitive processes and neuroimaging findings in a search for candidate keys to the intricate connections between neurodevelopment and neuroprogression in schizophrenia. In the complete panorama, schizophrenia is a neurodevelopmental disorder, possibly associated with an additional burden over the course of the disease through pathologically accelerated aging, and cognitive heterogeneity may explain the different trajectories of each patient.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Type d'étude:
Étude pronostique
langue:
Anglais
Texte intégral:
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
Thème du journal:
Psychiatrie
Année:
2022
Type:
Article
/
descriptif de projet
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Hospital de Clínicas de Porto Alegre (HCPA)/BR
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