Los virus herpes humanos 4 (virus de Epstein-Barr) y 6 (HHV-6) en las enfermedades de Hodgkin y de Kikuchi, y su relación con proliferación y apoptosis / Human herpes viruses 4 (viruses Epstein-Barr) and 6 (HHV-6) in the Hodgkin's and Kikuchi's diseases, and its relationship with proliferation and apoptosis
Salud(i)ciencia (Impresa)
;
12(3): 24-28, 2004. tab.
Article
Dans Espagnol
| LILACS
| ID: biblio-1363996
ABSTRACT
Background:
Epstein-Barr virus/EBV and HHV-6 are frequently found in Hodgkin's disease (HD) and to a certain extent in Kikuchi-Fujimoto's disease (KFD). Both viruses are apparently related to proliferative and/or apoptotic processes as represented by HD or KFD respectively.Objective:
To correlate frequency and location of antigen and DNA expression of both viruses in HD or KFD tissue sections in relation to markers for cell proliferation and apoptosis.Design:
Archival lymph node biopsies from 84 patients from the Hospital General de Mexico and 26 from the Clinic of the University of Cologne, Germany with HD and 14 with KFD were investigated immunhistologically for viral antigen expression (EBV LMP-1 HHV-6 gp110/60), Ki67/PCNA marker for proliferation (MIB1)/p53 and WAF1 for apoptosis. Viral ADN was shown by in situ hybridization. Apoptosis was determined by ISEL and TUNEL techniques.Results:
HD is frequently infected by both EBV and HHV-6 while KFD tends to be infected only by HHV-6. EBV and HD is present in HD cells and Reed-Sternberg cells, HHV-6 preferentially in lymphocytes and in histiocytes in both HD and in KFD. Proliferation marker is found in both diseases. Apoptosis is demonstrated preferentially in KFD and to a lesser extent also in HD.Conclusion:
Although EBV and HHV-6 may not be openly oncogenic in HD and KFD, they may well influence the course of the disease. Dual infection in HD appears to support proliferative processes,i.e. a redominance of EBV effects. Single infection with HHV-6 in KFD instead appears to favor an apoptotic course. These effects are according to the literature possibly cytokine-mediated.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Maladie de Hodgkin
/
Herpèsvirus humain de type 6
/
Herpèsvirus humain de type 4
/
Zona
langue:
Espagnol
Texte intégral:
Salud(i)ciencia (Impresa)
Thème du journal:
Science
/
Médicament
Année:
2004
Type:
Article
Pays d'affiliation:
Mexique
Institution/Pays d'affiliation:
Subjefe del Banco de Sangre. Profesora de Epidemiología Clínica de la Facultad de Medicina. Departamento de Salud Pública. Universidad Nacional Autónoma de México (UNAM)/MX
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