Comparison of plasma lipid profiles and atherogenic indices among hypertensives with or without type 2 diabetes
Sahel medical journal (Print)
;
25(1): 21-27, 2022. figures, tables
Article
Dans Anglais
| AIM
| ID: biblio-1379227
ABSTRACT
Background:
Several atherogenic indices derived from the lipid profiles are postulated to better detect dyslipidemias and predict the risk of having cardiovascular events even in the presence of insignificant changes in individual lipid parameters.Objective:
To compare the lipid ratios and atherogenic index of plasma (AIP) to conventional atherogenic indices among hypertensive type 2 diabetics to hypertensive nondiabetes (HND) controls. Materials andMethods:
A casecontrol study in which 210 participants with type 2 diabetes mellitus with hypertension (hypertensivediabetic [HD]) compared with 150 (n = 155) hypertensive without diabetes (HND) with similar ages were enrolled. Blood samples for fasting lipid profile were collected and analyzed, and the following indices and ratios were calculated (TC/highdensity lipoproteincholesterol [HDLC]), (lowdensity lipoproteincholesterol [LDLC]/HDLC), (HDLC/ LDLC), and AIP. The indices were compared in both the participants and control group.Results:
There was no significant difference in the clinical characteristics of HD compared to the HND except the systolic blood pressure, weight, and HDLC which were lower in the HND group. The frequency of dyslipidemia was found to be significantly higher in the HD group except elevated LDLC in males (25.8% vs. 17.4%, χ2 = 0.055, respectively). Furthermore, all the lipid ratios, except (Castelli risk index II [CRI II] were found to be significantly different among HD as compared to HND group (P = 0.002, P = 0.045, respectively).Conclusions:
This study concludes that Nigerians with both type 2 diabetes and hypertension have worse dyslipidemia and abnormal lipid ratios compared to those with only hypertension.
Texte intégral:
Disponible
Indice:
AIM (Afrique)
Sujet Principal:
Diabète de type 2
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Régime athérogène
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Hypertension artérielle
Type d'étude:
Étude observationnelle
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Étude pronostique
/
Facteurs de risque
langue:
Anglais
Texte intégral:
Sahel medical journal (Print)
Année:
2022
Type:
Article
Institution/Pays d'affiliation:
Department of Internal Medicine, Endocrinology, Diabetes and Metabolism Unit, College of Health Sciences/NG
/
Department of Medicine, College of Medicine, Bowen University and Bowen University Teaching Hospital, Ogbomoso/NG
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Department of Medicine, Endocrinology, Diabetes and Metabolism Unit, College of Medicine, University of Lagos/NG
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Obafemi Awolowo University Teaching Hospital Complex, Ile Ife/NG
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