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Outpatient haploidentical hematopoietic stem cell transplant using post-transplant cyclophosphamide and incidence of hemorrhagic cystitis
Gutiérrez Aguirre, Cesar Homero; Esparza Sandoval, Alejandra Celina; Palomares Leal, Alain; Jaime Pérez, José Carlos; Gómez Almaguer, David; Cantú Rodríguez, Olga Graciela.
Affiliation
  • Gutiérrez Aguirre, Cesar Homero; Universidad Autónoma de Nuevo León. University Hospital Dr. José E. González. Monterrey. MX
  • Esparza Sandoval, Alejandra Celina; Universidad Autónoma de Nuevo León. University Hospital Dr. José E. González. Monterrey. MX
  • Palomares Leal, Alain; Universidad Autónoma de Nuevo León. University Hospital Dr. José E. González. Monterrey. MX
  • Jaime Pérez, José Carlos; Universidad Autónoma de Nuevo León. University Hospital Dr. José E. González. Monterrey. MX
  • Gómez Almaguer, David; Universidad Autónoma de Nuevo León. University Hospital Dr. José E. González. Monterrey. MX
  • Cantú Rodríguez, Olga Graciela; Universidad Autónoma de Nuevo León. University Hospital Dr. José E. González. Monterrey. MX
Hematol., Transfus. Cell Ther. (Impr.) ; 44(2): 163-168, Apr.-June 2022. tab, graf
Article de En | LILACS | ID: biblio-1385054
Bibliothèque responsable: BR408.1
Localisation: BR408.1
ABSTRACT
Abstract Introduction Hemorrhagic cystitis (HC) is a common complication of haploidentical hematopoietic stem cell transplantation (haplo-HSCT), characterized by irritative symptoms of the urinary tract and a higher morbidity and mortality rate. The worldwide incidence is reported between 10% and 70%. The use of alkylating agents and BK viral infection are the most frequent etiologies. The aim of this study was to report the HC incidence in an outpatient haplo-HCST program with a reduced intensity-conditioning (RIC) regimen, cataloguing risk factors, complications and final outcomes. Methods The medical database of patients who received a haplo-HSCT between January 2012 and November 2017 was retrospectively analyzed. Demographic variables, general characteristics and HC incidence were included. Results One hundred and eleven patients were included, 30 (27%) of whom developed HC, most of them (70%) being grade II, with a 30-day (7-149) median time of post-transplant HC onset. The BK virus was detected in 71% of the urine samples analyzed. All HC patients responded to treatment, except two (6.6%), who died due to HC complications. Conclusions There was no difference in the HC incidence or severity, compared to that reported when performing haplo-HSCT in hospitalized patients, although the donor-recipient sex mismatch did relate to a higher HC incidence.
Sujet(s)
Mots clés

Texte intégral: 1 Indice: LILACS Sujet Principal: Virus BK / Transplantation de cellules souches hématopoïétiques / Cystite / Greffe haplo-identique Type d'étude: Incidence_studies / Prognostic_studies / Risk_factors_studies Limites du sujet: Adolescent / Adult / Child / Child, preschool / Female / Humans / Male langue: En Texte intégral: Hematol., Transfus. Cell Ther. (Impr.) Thème du journal: Hematologia / TransfusÆo de Sangue Année: 2022 Type: Article

Texte intégral: 1 Indice: LILACS Sujet Principal: Virus BK / Transplantation de cellules souches hématopoïétiques / Cystite / Greffe haplo-identique Type d'étude: Incidence_studies / Prognostic_studies / Risk_factors_studies Limites du sujet: Adolescent / Adult / Child / Child, preschool / Female / Humans / Male langue: En Texte intégral: Hematol., Transfus. Cell Ther. (Impr.) Thème du journal: Hematologia / TransfusÆo de Sangue Année: 2022 Type: Article