9p21 Locus Polymorphisms: Risk and Severity Factors of Coronary Artery Disease in Venezuelan Patients
Int. j. cardiovasc. sci. (Impr.)
;
35(4): 434-443, July-Aug. 2022. tab
Article
Dans Anglais
| LILACS
| ID: biblio-1385265
ABSTRACT
Abstract Background:
The 9p21 region is the most relevant locus associated with coronary heart disease in different populations. However, there are no studies that prove that this region is a risk factor in the Venezuelan population.Objectives:
To analyze whether or not the 9p21 rs1333049 polymorphism is a risk factor for acute myocardial infarction (AMI) in Venezuelan patients, as well as to investigate its correlation with cardiovascular risk factors (CVRF), age of occurrence, type and severity of infarction, and the correlation of the rs10757274 polymorphism with severity of coronary artery disease.Methods:
This was an association study, including 487 unrelated Venezuelan individuals, grouped in 354 patients with AMI and 133 controls. The rs1333049 and rs10757274 polymorphisms were determined using the polymerase chain reaction (PCR) technique with sequence-specific primers. The analysis of association was determined using the SNPStats tool. The continuous variable description and the correlations were performed using the SPSS statistical software. Significance was established at p<0.05.Results:
A positive correlation was observed between the rs1333049 polymorphism and the presence of hypertension ( r 0.145, p 0.006), and between hypertension and heart infarction ( r 0.318, p <0.0001). A positive correlation was found between the rs10757274 polymorphism and the number of coronary vessels that presented obstructive lesions in patients aged ≤ 55 years ( r 0.276, p 0.0078).Conclusion:
The rs1333049 polymorphism at the 9p21 locus is correlated with hypertension in Venezuelan patients, while the rs10757274 polymorphism is associated with the progression of coronary atherosclerosis, suggested by the correlation with the number of coronary vessels that presented significant obstructive lesions.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Maladie des artères coronaires
/
Chromosomes
Type d'étude:
Essai clinique contrôlé
/
Etude d'étiologie
/
Étude observationnelle
/
Facteurs de risque
Limites du sujet:
Adulte
/
Adulte très âgé
/
Aged80
/
Femelle
/
Humains
/
Mâle
Pays comme sujet:
Amérique du Sud
/
Vénézuela
langue:
Anglais
Texte intégral:
Int. j. cardiovasc. sci. (Impr.)
Thème du journal:
Cardiologie
Année:
2022
Type:
Article
Pays d'affiliation:
Venezuela
Institution/Pays d'affiliation:
Hospital Central del Instituto Venezolano de los Seguros Sociales Dr. Miguel Pérez Carreño/VE
/
Hospital General del Este Dr. Domingo Luciani/VE
/
Instituto Venezolano de Investigaciones Científicas/VE
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS