Farmacogenómica de los anticoagulantes orales: la importancia de establecer algoritmos de dosificación en población chilena
Rev. méd. Chile
;
148(9)sept. 2020.
Article
Dans Espagnol
| LILACS
| ID: biblio-1389314
ABSTRACT
There is an important interindividual variability in dose requirement for coumarinic anticoagulants, which could be explained by genetic and non-genetic factors. Among hereditary factors, there are gene polymorphisms that code the therapeutic target and the main enzyme responsible for their metabolism. However, there are other candidate genes that could modulate dose requirements. The is a paucity of pharmacogenomic platforms to determine dose requirements of coumarinics in the Chilean population. Therefore, algorithms considering different variables to adjust individual dosages are required. Herein, we analyze the available evidence about factors that can modify the effects of vitamin K antagonists and that should be incorporated to dosing algorithms.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Pharmacogénétique
/
Vitamine K
Type d'étude:
Étude pronostique
Limites du sujet:
Humains
Pays comme sujet:
Amérique du Sud
/
Chili
langue:
Espagnol
Texte intégral:
Rev. méd. Chile
Thème du journal:
Médicament
Année:
2020
Type:
Article
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