Puesta al día: carcinoma paratiroideo / An update on parathyroid carcinoma
Rev. méd. Chile
;
149(3): 399-408, mar. 2021. tab, ilus
Article
Dans Espagnol
| LILACS
| ID: biblio-1389472
ABSTRACT
Parathyroid carcinoma is a rare malignant disease that presents as a sporadic or familial primary hyperparathyroidism (PHP). The latter is associated with some genetic syndromes. It occurs with equal frequency in both sexes, unlike PHP caused by parathyroid adenoma that is more common in women. It should be suspected in cases of severe hypercalcemia, with high parathyroid hormone levels and a palpable cervical mass. Given the difficulty in distinguishing between parathyroid carcinoma and adenoma prior to the surgery, the diagnosis is often made after parathyroidectomy. The only curative treatment is complete surgical resection with oncologic block resection of the primary tumor to ensure free margins. Adjuvant therapies with chemotherapy or radiation therapy do not modify overall or disease-free survival. Recurrences are common and re-operation of resectable recurrent disease is recommended. The palliative treatment of symptomatic hypercalcemia is crucial in persistent or recurrent disease after surgery since morbidity and mortality are more associated with hypercalcemia than with tumor burden.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Tumeurs de la parathyroïde
/
Hyperparathyroïdie primitive
/
Hypercalcémie
Limites du sujet:
Femelle
/
Humains
/
Mâle
langue:
Espagnol
Texte intégral:
Rev. méd. Chile
Thème du journal:
Médicament
Année:
2021
Type:
Article
Pays d'affiliation:
Chili
Institution/Pays d'affiliation:
Clínica Alemana/CL
/
Clínica Dávila/CL
/
Clínica Indisa/CL
/
Clínica Las Condes/CL
/
Hospital Clínico Universidad de Chile/CL
/
Hospital Dipreca/CL
/
Pontificia Universidad Católica de Chile/CL
/
Universidad Finis Terrae/CL
/
Universidad de Concepción/CL
/
Universidad de los Andes/CL
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