Simultaneous determination of paracetamol, dextromethorphan, chlorpheniramine, pseudoephedrine and major impurities of paracetamol and pseudoephedrine by using capillary electrophoresis
Braz. J. Pharm. Sci. (Online)
;
58: e19836, 2022. tab, graf
Article
Dans Anglais
| LILACS
| ID: biblio-1394041
ABSTRACT
Abstract A capillary electrophoresis method was developed for the first time and optimized for the determination of paracetamol, pseudoephedrine, dextromethorphan, chlorpheniramine, 4-aminophenol and ephedrine in tablet formulation. Optimum electrophoretic conditions were achieved by using a background electrolyte of 75 mmol L-1 sodium borate buffer at pH 8.0, a capillary temperature of 30°C, a separation voltage of 30 kV and a pressure injection of the sample at 50 mbar for 10 s. Calibration graphs showed a good linearity with a coefficient of determination (R2) of at least 0.999 for all compounds. Intraday and interday precision (expressed as relative standard deviation (RSD) %) were lower than 1.39% for capillary electrophoresis method. The developed method was demonstrated to be simple and rapid for the determination of paracetamol, pseudoephedrine, dextromethorphan, chlorpheniramine, 4-aminophenol and ephedrine in tablet formulation providing recoveries in the range between 99.62 and 100.57% for all analytes.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Chlorphénamine
/
Électrophorèse capillaire
/
Dextrométhorphane
/
Éphédrine
/
Pseudoéphédrine
/
Aminophénols
/
Acétaminophène
Type d'étude:
Etude diagnostique
langue:
Anglais
Texte intégral:
Braz. J. Pharm. Sci. (Online)
Thème du journal:
Farmacologia
/
Teraputica
/
Toxicologia
Année:
2022
Type:
Article
Pays d'affiliation:
Turquie
Institution/Pays d'affiliation:
Ankara University/TR
/
Gazi University/TR
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