Lack of association of the KIR and HLA class I ligands with ZIKV infection in south and southeast of Brazil
Mem. Inst. Oswaldo Cruz
;
117: e210194, 2022. tab
Article
Dans Anglais
|
LILACS-Express
| LILACS
| ID: biblio-1394475
ABSTRACT
BACKGROUND Zika virus (ZIKV) is an emerging arbovirus associated with foetal malformations and neurological complications. The infection is usually associated with mild symptoms. The comparison between the allelic frequency of polymorphic genes in symptomatic infected individuals in the population can clarify the pathogenic mechanisms of ZIKV. During ZIKV infection, cytokines are produced and natural killer (NK) cells are recruited, whose activation depends on signaling pathways activated by specific receptors, such as killer cell immunoglobulin-like receptors (KIR). These molecules interact with human leukocyte antigen (HLA) class I ligands and are encoded by polymorphic genes. OBJECTIVES This study aimed to evaluate the frequency of allelic variants of the genes encoding the KIR receptors and their HLA class I ligands in 139 symptomatic ZIKV-patients and 170 controls negative for the virus, and to evaluate the role of these variants for ZIKV susceptibility. METHODS KIR and HLA class I genes were genotyped using the polymerase chain reaction-sequence specific oligonucleotide (PCR-SSO) technique. FINDINGS No significant differences in the frequency distribution of KIRs and KIR-HLA in patients compared to controls were observed. MAIN CONCLUSIONS KIR and its HLA ligands might play a minor role in ZIKV infection in the south and southeast Brazilian individuals.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Type d'étude:
Facteurs de risque
Pays comme sujet:
Amérique du Sud
/
Brésil
langue:
Anglais
Texte intégral:
Mem. Inst. Oswaldo Cruz
Thème du journal:
Médecine tropicale
/
Parasitologie
Année:
2022
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
15ª Regional de Saúde do Paraná/BR
/
Departamento de Vigilância em Saúde Pública de Campinas/BR
/
Faculdade de Medicina de São José do Rio Preto/BR
/
Farmacêutica responsável pelo Laboratório da Unidade Central de Nova Prata do Iguaçu/BR
/
Universidade Estadual de Campinas/BR
/
Universidade Estadual de Maringá/BR
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