The role of IFN-γ production during retroviral infections: an important cytokine involved in chronic inflammation and pathogenesis
Rev. Inst. Med. Trop. São Paulo (Online)
;
64: e64, 2022. graf
Article
Dans Anglais
|
LILACS-Express
| LILACS
| ID: biblio-1406891
ABSTRACT
ABSTRACT Interferon-gamma (IFN-γ) plays a crucial role in viral infections by preventing viral replication and in the promotion of innate and adaptive immune responses. However, IFN-gamma can exert distinct effects in different persistent viral infections. The long-term overproduction of IFN-γ in retroviral infections, such as the human immunodeficiency virus (HIV), human T-lymphotropic virus type 1 (HTLV-1), and human endogenous retroviruses (HERVs), resulting in inflammation, may cause neuronal damage. This review is provocative about the role of IFN-γ during persistent retroviral infections and its relationship with the causation of some neurological disorders that are important for public health.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Type d'étude:
Etude d'étiologie
langue:
Anglais
Texte intégral:
Rev. Inst. Med. Trop. São Paulo (Online)
Thème du journal:
Medicina Tropical
Année:
2022
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Universidade de São Paulo/BR
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