Alcohol consumption is associated with excessive risk of multiple sclerosis: a meta-analysis observational study
São Paulo med. j
;
140(4): 518-524, July-Aug. 2022. tab, graf
Article
Dans Anglais
|
LILACS-Express
| LILACS
| ID: biblio-1410195
ABSTRACT
ABSTRACT BACKGROUND:
There have been inconsistent results regarding the association between alcohol intake and susceptibility to multiple sclerosis.OBJECTIVE:
To assess the potential role of alcohol intake regarding the risk of multiple sclerosis by using a meta-analytic approach. DESIGN ANDSETTING:
Observational meta-analysis study conducted in a hospital in China.METHODS:
The electronic databases of PubMed, EMBASE and the Cochrane library were systematically searched for eligible studies from their inception up to January 2020. The summary odds ratio (OR) with 95% confidence interval (CI) was applied to assess the association between alcohol intake and multiple sclerosis, using a random-effects model.RESULTS:
One prospective cohort study and eight case-control studies involving a total of 211,396 subjects and 10,407 cases of multiple sclerosis were selected for the final meta-analysis. From the pooled data, no significant association between alcohol intake and multiple sclerosis risk was found (OR 0.94; 95% CI 0.73-1.22; P = 0.668), and this conclusion was judged to be robust. Subgroup analysis found that intake of beer was associated with an increased risk of multiple sclerosis (OR 1.58; 95% CI 1.12-2.23; P = 0.010).CONCLUSION:
This study found that beer intake could cause an excess risk of multiple sclerosis. Further large-scale prospective studies should be conducted to verify this conclusion.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Type d'étude:
Etude d'étiologie
/
Étude observationnelle
/
Facteurs de risque
/
Revues systématiques évaluées
langue:
Anglais
Texte intégral:
São Paulo med. j
Thème du journal:
Cirurgia Geral
/
Cincia
/
Ginecologia
/
Médicament
/
Medicina Interna
/
Obstetr¡cia
/
Pediatria
/
Sa£de Mental
/
Sa£de P£blica
Année:
2022
Type:
Article
Pays d'affiliation:
Chine
Institution/Pays d'affiliation:
Department of Neurology/CN
/
Department of Operating Theatre/CN
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