Development and characterization of PLGA-Bupivacaine and PLGA-S75: R25 Bupivacaine (Novabupi®) biodegradable implants for postoperative pain
Braz. J. Pharm. Sci. (Online)
;
58: e21310, 2022. graf
Article
Dans Anglais
| LILACS
| ID: biblio-1420508
ABSTRACT
Abstract In the hospital environment, postoperative pain is a common occurrence that impairs patient recovery and rehabilitation and lengthens hospitalization time. Racemic bupivacaine hydrochloride (CBV) and Novabupi® (NBV) (S (-) 75% R (+) 25% bupivacaine hydrochloride) are two examples of local anesthetics used in pain management, the latter being an alternative with less deleterious effects. In the present study, biodegradable implants were developed using Poly(L-lactide-co-glycolide) through a hot molding technique, evaluating their physicochemical properties and their in vitro drug release. Different proportions of drugs and polymer were tested, and the proportion of 25%75% was the most stable for molding the implants. Thermal and spectrometric analyses were performed, and they revealed no unwanted chemical interactions between drugs and polymer. They also confirmed that heating and freeze-drying used for manufacturing did not interfere with stability. The in vitro release results revealed drugs sustained release, reaching 64% for NBV-PLGA and 52% for CBV-PLGA up to 30 days. The drug release mechanism was confirmed by microscopy, which involved pores formation and polymeric erosion, visualized in the first 72 h of the in vitro release test. These findings suggest that the developed implants are interesting alternatives to control postoperative pain efficiently.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Douleur postopératoire
/
Bupivacaïne
/
Implant résorbable
/
Anesthésiques locaux
langue:
Anglais
Texte intégral:
Braz. J. Pharm. Sci. (Online)
Thème du journal:
Farmacologia
/
Teraputica
/
Toxicologia
Année:
2022
Type:
Article
Pays d'affiliation:
Brésil
/
Irlande
/
États-Unis d'Amérique
Institution/Pays d'affiliation:
Federal University of Espírito Santo/BR
/
Federal University of Minas Gerais/BR
/
National University of Ireland Galway/IE
/
Stanford University/US
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