Non-alcoholic fatty liver disease and thrombocytopenia IV: its association with granulocytopenia
Hematol., Transfus. Cell Ther. (Impr.)
;
44(4): 491-496, Oct.-dec. 2022. tab, graf
Article
Dans Anglais
| LILACS
| ID: biblio-1421533
ABSTRACT
ABSTRACT Introduction:
We have previously shown that some patients present thrombocytopenia (less than 100 × 109/L platelets) in non-alcoholic fatty liver disease (NAFLD). To further explore the nature of this association, we have now analyzed the association of thrombocytopenia with neutropenia (less than 0.5 × 109/L granulocytes) in NAFLD. Material andmethods:
Persons with NAFLD were prospectively accrued in the study after February 2018. The presence of NAFLD was defined by both serologic determinations (Fibromax ®) and liver transient elastography (TE/Fibroscan ®).Results:
In 123 consecutive patients with NAFLD without cirrhosis, thrombocytopenia was identified in 20 (16%), whereas neutropenia was identified in 9 (7%). In the subset of 20 patients with NAFLD and thrombocytopenia, granulocytopenia was identified in 5 (25%), whereas in the subset of 9 patients with granulocytopenia, thrombocytopenia was identified in 5 (55%). We found a significant association between thrombocytopenia and both leukopenia and granulocytopenia (OR 8.25, 95% CI 1.9-34.2, p = 0.004).Conclusions:
Both thrombocytopenia and neutropenia were identified in persons with NAFLD and, as there is a significant relationship between these two variables, we speculate that this finding may support the possibility of hypersplenism being involved in the cytopenias found in NAFLD without cirrhosis.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Thrombopénie
/
Agranulocytose
/
Stéatose hépatique non alcoolique
Type d'étude:
Étude pronostique
/
Facteurs de risque
langue:
Anglais
Texte intégral:
Hematol., Transfus. Cell Ther. (Impr.)
Thème du journal:
Hematologia
/
TransfusÆo de Sangue
Année:
2022
Type:
Article
Pays d'affiliation:
Mexique
Institution/Pays d'affiliation:
Laboratorios Clínicos de Puebla/MX
/
Universidad Popular Autónoma del Estado de Puebla/MX
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