Inflammation and Nocturnal Pattern of Blood Pressure in Normotensives
Int. j. cardiovasc. sci. (Impr.)
;
34(6): 685-691, Nov.-Dec. 2021. tab, graf
Article
Dans Anglais
|
LILACS-Express
| LILACS
| ID: biblio-1421743
ABSTRACT
Abstract Background:
In most healthy individuals, blood pressure (BP) shows a circadian rhythm. Being non-dipper increases cardiovascular risk in normotensive and hypertensive individuals. Nocturnal dipping shows a correlation with the state of inflammation. Objetive To investigate the relationship between inflammation-based indexes and nocturnal BP pattern in normotensive individuals.Method:
This is a retrospective study that included patients evaluated with ambulatory BP monitoring (ABPM). A total of 131 normotensive individuals were included and grouped as dippers and non-dippers. The normality of the data was verified with a Shapiro-Wilk test. We compared ABPM variables and inflammation-based indexes derived from blood tests (monocyte to high-density lipoprotein ratio [MHR], platelet to lymphocyte ratio [PLR], neutrophil to lymphocyte ratio [NLR], and systemic immune-inflammation index [SII]) between groups. The independent samples t-test and Mann-Whitney U test were used for comparing variables with normal and non-normal distributions, respectively. The Pearson's chi-squared test was used to compare categorical variables, and Spearman's correlation coefficient was used to examine the relationships between variables. A receiver operating characteristic (ROC) curve was used to evaluate the diagnostic performances of inflammation-based indexes. The level of statistical significance was 5%.Results:
The study included 131 patients (mean±standard deviation [SD] age 49.2±15.1 years, 58 [76.0%] of which were women). SII was significantly higher in the non-dipper group (p=0.033). Significant negative correlations were observed between the change in systolic BP [ΔSBP] and SII (r=-0.172, p=0.049) and between ΔSBP and PLR (r=-0.179, p=0.040).Conclusion:
SII is a predictor of nocturnal BP pattern in normotensives.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Type d'étude:
Étude observationnelle
/
Étude pronostique
/
Facteurs de risque
langue:
Anglais
Texte intégral:
Int. j. cardiovasc. sci. (Impr.)
Thème du journal:
Cardiologie
Année:
2021
Type:
Article
Pays d'affiliation:
Turquie
Institution/Pays d'affiliation:
Bursa Uludag University/TR
/
Istanbul Bahçelievler State Hospital/TR
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