Human beta-defensin 1 circulating level and gene polymorphism in non-segmental vitiligo Egyptian patients
An. bras. dermatol
; 98(2): 181-188, March.-Apr. 2023. tab, graf
Article
Dans En
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LILACS-Express
| LILACS
| ID: biblio-1429664
Responsable en Bibliothèque :
BR1.1
ABSTRACT
Abstract Background:
Vitiligo is an acquired depigmented skin disorder. It has a genetic and autoimmune background. Human beta defensin-1(HBD-1) plus its gene polymorphism were linked to some autoimmune disorders.Objectives:
To elucidate the possible role of HBD-1 in the pathogenesis of non-segmental vitiligo (NSV) through evaluation of HBD-1 serum levels and its single nucleotide polymorphism (SNP) in patients having NSV, in addition, to correlating the results with the extent of vitiligo in those patients.Methods:
A current case-control study included 50 patients having NSV and 50 controls. The authors used Vitiligo Area Scoring Index (VASI) score to assess vitiligo severity and laboratory investigations to assess serum HBD-1 level using ELISA and defensin-beta1 (DEFB1) SNP using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).Results:
There were significantly lower HBD-1 serum levels in NSV cases than in controls (p < 0.001). There was a significant predominance of GG DEFB1 genotype and G allele in NSV patients in comparison to controls (p < 0.001). The levels of serum HBD-1 and DEFB1 genotypes were not associated or correlated significantly with any of the personal and clinical parameters of vitiligo patients. Studylimitations:
The small sample size.Conclusions:
DEFB1 gene polymorphism (GG genotype and G allele) may modulate vitiligo risk and contribute to vitiligo development in Egyptian populations. Decreased circulating HBD-1 levels might have an active role in vitiligo etiopathogenesis that could be mediated through its possible anti-inflammatory effects.
Texte intégral:
1
Indice:
LILACS
Type d'étude:
Observational_studies
/
Risk_factors_studies
langue:
En
Texte intégral:
An. bras. dermatol
Thème du journal:
DERMATOLOGIA
Année:
2023
Type:
Article