Biochemical and immunohistochemical examination of the effects of ephedrine in rat ovary tissue
Acta cir. bras
;
38: e381523, 2023. tab, ilus
Article
Dans Anglais
| LILACS, VETINDEX
| ID: biblio-1439109
ABSTRACT
Purpose:
It was aimed to investigate the biochemical and immunohistochemical effects of ephedrine (EPH) in bilateral ovariectomized rats.Methods:
Twenty-four Sprague Dawley female rats were divided into three groups control group The abdomen was opened and closed without any treatment; ischemia-reperfusion (IR) group 2 h of ischemia followed by 2 h of reperfusion were allowed to cause IR injury; IR+EPH group oral EPH solution (5 mg/kg) was administered for 28 days.Results:
Biochemical parameters were statistically significant in group comparisons. Increased interleukin-6 (IL-6) expression, degenerative preantral and antral follicle cells and inflammatory cells around blood vessels were seen in IR group. Negative IL-6 expression was observed in seminal epithelial cells, preantral and antral follicle cells in IR+EPH group. While caspase-3 activity increased in granulosa cells and stromal cells in IR group, caspase-3 expression was negative in preantral and antral follicle cells in the germinal epithelium and cortex in IR+EPH group.Conclusion:
The effect of apoptosis, which occurs with the signaling that starts in the cell nucleus, caused the cessation of the stimulating effect at the nuclear level after EPH administration, and a decrease in the antioxidative effect in IR damage and inflammation in the apoptotic process.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Ovaire
/
Interleukine-6
/
Éphédrine
/
Caspase-3
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Acta cir. bras
Année:
2023
Type:
Article
Institution/Pays d'affiliation:
Dicle University/TR
/
Diyarbakir Memorial Hospital/TR
/
Private Medical Practice/TR
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