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The relationship of major depressive disorder with Crohn's disease activity
Facanali, Carolina Bortolozzo Graciolli; Sobrado Junior, Carlos Walter; Fraguas Junior, Renério; Facanali Junior, Marcio Roberto; Boarini, Lucas Rodrigues; Sobrado, Lucas Faraco; Cecconello, Ivan.
  • Facanali, Carolina Bortolozzo Graciolli; Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. São Paulo. BR
  • Sobrado Junior, Carlos Walter; Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. São Paulo. BR
  • Fraguas Junior, Renério; Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. São Paulo. BR
  • Facanali Junior, Marcio Roberto; Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. São Paulo. BR
  • Boarini, Lucas Rodrigues; Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. São Paulo. BR
  • Sobrado, Lucas Faraco; Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. São Paulo. BR
  • Cecconello, Ivan; Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. São Paulo. BR
Clinics ; 78: 100188, 2023. tab, graf
Article Dans Anglais | LILACS-Express | LILACS | ID: biblio-1439901
ABSTRACT
Abstract

Introduction:

Crohn's disease (CD) has been related to an increased prevalence of psychiatric disorders and suicide risk (SR). However, the nature of their relationship still deserves clarification. The aim of this study is to assess the prevalence of major depressive disorder (MDD) in patients with CD, and to investigate the relationship between MDD and CD outcomes.

Methods:

A cross-sectional study involving CD patients was performed. CD activity was evaluated by the Harvey-Bradshaw index and CD phenotype by the Montreal classification. The presence of MDD was assessed by the Patient Health Questionnaire score-9 (PHQ-9). Sociodemographic data and other characteristics were retrieved from electronic medical records.

Results:

283 patients with CD were included. The prevalence of MDD was 41.7%. Females had a risk of MDD 5.3 times greater than males. CD disease duration was inversely correlated with MDD severity. Individuals with active CD were more likely to have MDD (OR = 796.0; 95% CI 133.7‒4738.8) than individuals with CD remission. MDD was more prevalent in inflammatory behavior (45.5%) and there were no statistical differences regarding the disease location. 19.8% of the sample scored positive for SR.

Conclusion:

The present results support data showing an increased prevalence of MDD in individuals with CD. Additionally, it indicates that MDD in CD might be related to the activity of CD. Prospective studies are warranted to confirm these results and to address whether MDD leads to CD activity, CD activity leads to MDD or both ways are existent.


Texte intégral: Disponible Indice: LILAS (Amériques) Type d'étude: Étude observationnelle / Facteurs de risque langue: Anglais Texte intégral: Clinics Thème du journal: Médicament Année: 2023 Type: Article Pays d'affiliation: Brésil Institution/Pays d'affiliation: Universidade de São Paulo/BR

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Texte intégral: Disponible Indice: LILAS (Amériques) Type d'étude: Étude observationnelle / Facteurs de risque langue: Anglais Texte intégral: Clinics Thème du journal: Médicament Année: 2023 Type: Article Pays d'affiliation: Brésil Institution/Pays d'affiliation: Universidade de São Paulo/BR